Search for dissertations about: "Dihydrofolate reductase"
Showing result 1 - 5 of 13 swedish dissertations containing the words Dihydrofolate reductase.
-
1. Approaches to soft drug analogues of dihydrofolate reductase inhibitors : Design and synthesis
Abstract : The main objective of the research described in this thesis has been the design and synthesis of inhibitors of the enzyme dihydrofolate reductase (DHFR) intended for local administration and devoid of systemic side-effects. The blocking of the enzymatic activity of DHFR is a key element in the treatment of many diseases, including cancer, bacterial and protozoal infections, and also opportunistic infections associated with AIDS (Pneumocystis carinii pneumonia, PCP). READ MORE
-
2. Computational prediction of receptor-ligand binding affinity in drug discovery
Abstract : The evaluation of inhibition constants or, more generally, receptor-ligand binding affinities is a crucial part of the drug discovery process. Chemical synthesis and affinity screening is only affordable for a limited number of compounds. This makes computational methods to predict binding affinities of candidate ligands highly desirable. READ MORE
-
3. Studies on dihydrofolate reductase and trimethoprim resistance in Escherichia coli
Abstract : .... READ MORE
-
4. Computer Simulation of Protein Tyrosine Phosphatase Reaction Mechanisms and Dihydrofolate Reductase Inhibition
Abstract : Protein tyrosine phosphatases catalyse the hydrolysis of phosphotyrosine residues in proteins, which is an important reaction in the cell signalling system. The three dimensional structure of such a protein tyrosine phosphatase has been used in a computational study of the reaction mechanism at the atomic level. READ MORE
-
5. Malaria on islands : human and parasite diversities and implications for malaria control in Vanuatu
Abstract : The genetic diversities displayed by human and malaria parasites at different frequencies in different geographical areas represent a major obstacle for the development of malaria control strategies including malaria chemotherapy and malaria vaccine. We investigated some genetic diversities on Vanuatu islands with various malaria endemicities. READ MORE