Search for dissertations about: "Dihydrotestosterone"

Showing result 1 - 5 of 23 swedish dissertations containing the word Dihydrotestosterone.

  2. 1. Sex steroids, IGF-I, and vascular morphology from birth to adulthood in individuals born small for gestational age

    Author : Kerstin Allvin; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; small for gestational age; preterm; sex steroid; estradiol; testosterone; dihydrotestosterone; glucocorticoid; retina; IGF-I;

    Abstract : Abstract Aim: To study whether there is an association between size at birth, sex steroids, IGF-I, and retinal vascular morphology. Patients and methods: Two different cohorts were studied. In paper I, 25 young adult men born small for gestational age (SGA) were compared to 44 young adult men born appropriate for gestational age (AGA). READ MORE

  4. 2. Metabolic and ovarian consequences of perinatal sex steroid programming

    Author : Camilla Alexanderson; Göteborgs universitet; []
    Keywords : programming; sex steroids; insulin resistance; skeletal muscle; adipose tissue; ovary;

    Abstract : Endocrine and metabolic disturbances in adulthood may stem from insults such as nutritional and hormonal alterations that occur at critical periods in pre- or postnatal life – a process known as programming. This means that suboptimal conditions in utero and early life may contribute to adult reproductive and metabolic impairments such as type 2 diabetes, insulin resistance, and dyslipidemia. READ MORE

  5. 3. Regulation of Ovarian Aromatase: Studies by Aromatase Assays in vitro and in vivo

    Author : Dmitrijus Kirilovas; Mats Brännström; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics and gynaecology; aromatase; human; granulosa cells; 11C-vorozole; active site; allosteric configuration; in vitro; in vivo; PET; androgens; rat; estrous cycle.; Obstetrik och kvinnosjukdomar; Obstetrics and women s diseases; Obstetrik och kvinnosjukdomar; Obstetrics and Gynaecology; obstetrik och gynekologi;

    Abstract : An in vitro method was developed for measuring aromatase, based on binding of competitive aromatase inhibitor [11C]vorozole to the active site of the enzyme. [11C]Vorozole displayed high, specific binding in vitro to human placenta and human granulosa cells (GC), both fresh and frozen/thawed cells, provided correct procedures were used. READ MORE

  6. 4. Androgen receptors and endocrine disrupting substances

    Author : Anders Larsson; Per-Erik Olsson; Björn Brunström; Örebro universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Androgen receptor; Brominated flame retardant; TBECH; Endocrine disruptor; Biology; Biologi; NATURAL SCIENCES; NATURVETENSKAP; Biology; Biologi;

    Abstract : Throughout the animal kingdom, organisms are dependent on substances such as steroid hormones to help them maintain internal balances. Examples of important tasks that are under regulation of steroid hormones are somatic and gonadal development, sexual performance and behavior (both social and sexual) as well as sex differentiation. READ MORE

  7. 5. Clinical pharmacokinetic/pharmacodynamic modelling of 5a-reductase inhibitors for the treatment of benign prostatic hyperplasia

    Author : Per Olsson Gisleskog; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

    Abstract : Dihydrotestosterone (DHT), a potent androgen necessary for the development of benign prostatic hyperplasia (BPH) is formed from testosterone by the enzyme 5α-reductase, of which there are two types. The irreversible 5α-reductase inhibitors dutasteride, which inhibits both isozymes, and finasteride, which inhibits only one, are intended for the treatment of BPH. READ MORE