Search for dissertations about: "Dimers"

Showing result 11 - 15 of 169 swedish dissertations containing the word Dimers.

  2. 11. LL-37-derived cyclic antimicrobial drug leads : Design, synthesis, activity and different ways of creating them 

    Author : Taj Muhammad; Ulf Göransson; Sunithi Gunasekera; Adam A. Strömstedt; Wang Guangshun; Uppsala universitet; []
    Keywords : antimicrobial peptide; host defense; antimicrobial; LL-37; KR-12; peptide cyclisation; peptide dimerisation; croos-linking; cyanobactin-macrocyclase; PatGmac; butelase 1; enzymatic cyclisation; immobilisation; Farmakognosi; Pharmacognosy;

    Abstract : In an era where last-line antibiotics are failing, one of the powerful approaches to develop novel therapeutic agents is to turn back to nature in order to identify possible drug candidates. Among the potential candidates, antimicrobial peptides (AMPs) have garnered much attention as an antimicrobial. READ MORE

  4. 12. Synthesis of Oligosaccharides for Interaction Studies with Various Lectins

    Author : Emiliano Gemma; Stefan Oscarson; Martina Lahmann; Hans Kamerling; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi;

    Abstract : In this thesis, the syntheses of oligosaccharides for interaction studies with various lectins are described. The first section reports the syntheses of tetra, tri- and disaccharides corresponding to truncated versions of the glucosylated arm of Glc1Man9(GlcNAc)2, found in the biosynthesis of N-glycans. READ MORE

  5. 13. Roughening in dimer models : Random matrix statistics and surface fluctuations

    Author : Scott Mason; Kurt Johansson; Alexey Bufetov; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Matematik; Mathematics;

    Abstract : The field of mathematical statistical mechanics sits at the intersection of probability theory and mathematical physics. It consists of the rigorous analysis of models in statistical mechanics, such as dimer and lattice models - of which the Ising model is a classical example. READ MORE

  6. 14. Molecular Mechanisms in Amyloid Disorders. Novel Treatment Options in Hereditary Cystatin C Amyloid Angiopathy

    Author : Gustav Östner; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cystatin C; amyloid; amyloidosis; oligomers; domain swapping;

    Abstract : The pathophysiological process in Alzheimer’s disease and other amyloid disorders usually involves the transformation of a soluble monomeric protein via potentially toxic oligomers into amyloid fibrils. The structure and properties of the intermediary oligomers have been difficult to study due to their instability and dynamic equilibrium with smaller and larger species. READ MORE

  7. 15. Domain swapping as a molecular mechanism in amyloidosis

    Author : Maria Wahlbom; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical chemistry; Klinisk kemi; Medicin människa och djur ; Medicine human and vertebrates ; oligomer; dimer; domain swapping; fibril; cystatin C; amyloidosis;

    Abstract : Amyloidosis is a group of diseases characterized by a change in protein conformation resulting in aggregation and tissue deposition of amyloid fibrils. One variant of cystatin C, L68Q cystatin C, is highly amyloidogenic and persons carrying the corresponding gene suffer from massive cerebral amyloidosis leading to brain hemorrhage and death. READ MORE