Search for dissertations about: "Dina Mahmoud Ali"

Found 1 swedish dissertation containing the words Dina Mahmoud Ali.

  1. 1. Mechanistic studies of APR-246 in leukemia

    Author : Dina Mahmoud Ali; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : PRIMA-1and its analog APR-246 are novel drugs that restore the active conformation of mutated and unfolded p53 protein and induce apoptosis and cell death in various tumors in pre-clinical models. We first aimed to explore the effects of APR-246 alone and in combination with other drugs in acute myeloid leukemia (AML) in vitro. READ MORE