Search for dissertations about: "Dipyridophenazine"
Showing result 1 - 5 of 8 swedish dissertations containing the word Dipyridophenazine.
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1. Chemically Modified Oligonucleotides: Synthesis, Physicochemical and Biochemical Properties of their Duplexes with DNA and RNA
Abstract : This thesis is based on 9 papers dealing with the synthesis, physicochemical and biochemical properties of two types of chemically modified oligonucleotides which have the potential to down-regulate gene expression: (i) The first set is comprised of antisense oligonucleotides (AONs) conjugated with different chromophores of varying size, charge and π-electron density. Conjugation of the chromophores at the 3'- or 5'-end enhanced the target RNA binding affinity and RNase H recruitment capabilities compared to the native counterpart without changing the global helical conformation of their AON/RNA hybrid duplexes. READ MORE
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2. Retinoids and Ruthenium Complexes: Spectroscopic Probes for Lipid Membranes
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3. Polarized light spectroscopy studies of model membranes and DNA
Abstract : Over the past decades Linear Dichroism (LD) spectroscopy has proven to be a powerful tool for studies of structure and functioning of different cell constituents, including DNA, cell membranes and proteins. Due to structural complexity of cell constituents, the LD studies of biomolecules depend on development of simplified model systems, which can mimic the original structure and functionality of the cell components. READ MORE
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4. Probing Biomolecules and Membranes using Spectroscopy and Microscopy
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5. Cellular Dyes and Bioactive Peptides - Cell Membrane Interactions and Cellular Uptake
Abstract : Knowledge about mechanisms behind interactions of molecules with biomembranes and cellular uptake is very important for understanding biological processes and for drug design. The work described in this thesis has focused on interactions of cellular dyes and bioactive peptides with cells and the cell membrane. READ MORE