Search for dissertations about: "Direct acting antivirals"

Found 5 swedish dissertations containing the words Direct acting antivirals.

2. 1. Discovery and evaluation of direct acting antivirals against hepatitis C virus

   Author : Eldar Abdurakhmanov; Helena Danielson; David Frick; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Direct acting antivirals; Hepatitis C; NS3-4A protease; NS5B polymerase; structure-based drug discovery; fragment-based drug discovery; surface plasmon resonance; Biokemi; Biochemistry;

   Abstract : Until recently, the standard therapy for hepatitis C treatment has been interferon and ribavirin. Such treatment has only 50% efficacy and is not well tolerated. The emergence of new drugs has increased the treatment efficacy to 90%. READ MORE

4. 2. Study of Resistance in Hepatitis C Virus Prior to Treatment with Direct Acting Antivirals

   Author : Midori Kjellin; Johan Lennerstrand; Nina Weis; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatitis C; HCV; DAA; RAS; resistance-associated substitution; baseline resistance; NS5A; NS3; SVR; Medical Virology; Medicinsk virologi; Mikrobiologi; Microbiology; Infektionssjukdomar; Infectious Diseases;

   Abstract : The rapid advancement of Hepatitis C (HCV) treatment presents a great challenge to clinicians in optimising therapy for their patients. Genotype (GT), efficacy, side-effects, drug combinations and treatment durations must be tailored to individual patients, considering comorbidities, degree of fibrosis, adherence and antiviral resistance. READ MORE

5. 3. Impact of Genetic Variants in Inosine Triphosphate Pyrophosphatase and Interferon-λ4 on Natural History, Treatment Response and Ribavirin Pharmacology in Hepatitis C Virus Infection

   Author : Jesper Waldenström; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatitis C virus; HCV; Inosine triphosphate pyrophosphatase; ITPA; interferon-λ4; IFNL4; ribavirin; interferon; PWID; IP-10;

   Abstract : Hepatitis C virus (HCV) impacts on global health with around 70 million chronically infected worldwide. The infection increases the risk of cirrhosis and primary liver cancer. The treatment until 2013 has been based on interferon-α and ribavirin, but is now replaced by direct acting antivirals. READ MORE

6. 4. Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors : Targeting Different Genotypes and Drug-Resistant Variants

   Author : Anna Karin Belfrage; Anja Sandström; Ulf Ellervik; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; hepatitis C virus; HCV; NS3 protease inhibitors; structure-activity relationship; 2 1H -pyrazinone; quinazoline; resistance; Pd catalysis; Medicinal Chemistry; Läkemedelskemi; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Since the first approved hepatitis C virus (HCV) NS3 protease inhibitors in 2011, numerous direct acting antivirals (DAAs) have reached late stages of clinical trials. Today, several combination therapies, based on different DAAs, with or without the need of pegylated interferon-α injection, are available for chronic HCV infections. READ MORE

7. 5. HIV/HCV co-infection in Sweden : epidemiology, HCV treatment and the importance of IL28B gene polymorphism

   Author : Jenny Stenkvist; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Liver disease, mainly due to hepatitis C virus (HCV) infection, is a leading cause of death in HIV positive patients with access to antiretroviral therapy (ART). HCV treatment, which can prevent long-term complications of HCV infection, is available. Despite this, only a minority of HIV/HCV co-infected patients initiate HCV treatment. READ MORE