Search for dissertations about: "Disease Models"

Showing result 6 - 10 of 1335 swedish dissertations containing the words Disease Models.

2. 6. Mitochondria in Alzheimer's Disease : The Presequence Protease and Mitochondria-Associated ER Membranes

   Author : Catarina Moreira Pinho; Elzbieta Glaser; Paolo Bernardi; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Alzheimer s Disease; Mitochondria; Mitochondria-associated ER membranes; human Presequence Protease; Biochemistry; biokemi;

   Abstract : Alzheimer’s disease (AD) is one of the most prevalent age-related neurodegenerative disorders and the accumulation of the amyloid-β peptide (Aβ) in the temporal lobe has been implicated in the pathology of AD. Synaptic transmission in neuronal cells is a highly energy dependent process, which relies on the presence and proper function of mitochondria. READ MORE

4. 7. Amyloid-β Protofibril Formation and Neurotoxicity : Implications for Alzheimer’s Disease

   Author : Ann-Sofi Johansson; Lars Lannfelt; Frida Ekholm Pettersson; Pär Gellerfors; Tobias Hartmann; Uppsala universitet; []
   Keywords : Neurosciences; Amyloid-β; Neurotoxicity; Aggregation; Protofibrils; Alzheimer s disease; Neurovetenskap;

   Abstract : Alzheimer’s disease (AD) is the most common cause of dementia. A characteristic feature of AD is the presence of amyloid plaques in the cortex and hippocampus of the brain. The principal component of these plaques is the amyloid-β (Aβ) peptide, a cleavage product from proteolytic processing of amyloid precursor protein (APP). READ MORE

5. 8. Models and biomarkers of motor and neuropsychiatric complications in Parkinson’s disease

   Author : Katrine Skovgård; Basala gangliernas patofysiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease Parkinsonism; Dyskinesia; Drug-Induced; Oscillations; Local field potentials; Impulsive-compulsive behaviours; Dopamine agonists; Animal Models; Pharmacology;

   Abstract : Parkinson's disease (PD) is a neurodegenerative disorder characterised by typicalmotor symptoms that are caused by severe dopamine depletion in the cortico-basalganglia network. Parkinsonian motor symptoms are improved by dopaminergicmedications, the most effective being the dopamine precursor L-DOPA. READ MORE

6. 9. Experimental Chagas disease

   Author : John Andersson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Trypanosoma cruzi; NK cells; cytotoxicity; IFN-gamma; IL-12; IFN-alpha beta; Chagas disease; polymyositis; myocarditis; genotype dependence and Toll-like receptors.;

   Abstract : The main focus of this thesis was to develop and utilise experimental models using the protozoan parasite Trypanosoma cruzi. We were especially interested in studying the activation of NK cells early after T. cruzi infection and what factors that predispose to a chronic inflammatory disease after T. cruzi infection. READ MORE

7. 10. Neuropeptide expression in mouse disease models

   Author : Margarita Diez; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Alzheimers disease; autoradiographic ligand binding; CCK; degeneration; dynorphin; enkephalin; galanin; immunohistochemistry; in situ hybridization; lesion; magnetic resonance imaging; megencephaly; NPY; prion infection; substance P.;

   Abstract : The role of neuropeptides and the significance of peptidergic mechanisms in neurodegenerative diseases are still relatively unexplored. In the periphery, nerve injury results in dramatic changes in the expression of neuropeptides (and other molecules). READ MORE