Search for dissertations about: "Disease Vectors"

Showing result 11 - 15 of 101 swedish dissertations containing the words Disease Vectors.

  2. 11. Precision mapping of gene expression and proteins in the brain using gene editing and barcoded viral vectors

    Author : Martino Avallone; Molekylär neuromodulering; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gene editing; CRISPR Cas9; Barcodes; AAV; PLA; gene therapy; Parkinson’s disease; single nuclei RNAseq; alpha-synuclein;

    Abstract : The human brain is a masterpiece of intricate design and impeccable functionality. It serves as the ultimate command center for our thoughts, sensations, and actions, which define our very existence. READ MORE

  4. 12. Gene therapy by enzyme replacement for Parkinson’s disease Optimization of continuous DOPA delivery and development of a candidate vector for clinical application

    Author : Tomas Björklund; Brain Repair and Imaging in Neural Systems (BRAINS); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serotonin; Parkinson’s disease; L-DOPA; dyskinesia; GTP cyclohydrolase 1; tyrosine hydroxylase; dopamine; gene therapy; enzyme replacement; gene regulation; aromatic L-amino acid decarboxylase;

    Abstract : The introduction of L-DOPA pharmacotherapy revolutionized the treatment of Parkinson’s disease close to fifty years ago. Before the discovery of dopamine as a neurotransmitter and its involvement in the disease, these patients had very little aid from medication and were bound to a life without movement. READ MORE

  5. 13. Spatial modelling and simulation for disease surveillance

    Author : Mohammadreza Rajabi; Institutionen för naturgeografi och ekosystemvetenskap; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; GISgeografiska informationssystem; Agent Based Modeling; spatial epidemiology; machine learning;

    Abstract : This thesis addresses the application of spatial approaches to disease surveillance and control from three different aspects. First, temporal trends, geographical distribution and spatial pattern of cardiovascular disease admission rates were explored on a national level in Sweden. READ MORE

  6. 14. Development of lentiviral vectors for CNS gene transfer

    Author : Johan Jakobsson; Brain Repair and Imaging in Neural Systems (BRAINS); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; Biotechnology; Gene Therapy; Neurological disorders;

    Abstract : Gene therapy in the brain is a promising treatment strategy that in the future may be used for several brain disorders, including Parkinson's disease, Alzheimer's disease and lysosomal storage diseases. By introducing a new gene, rather than providing a classical pharmacological drug, gene therapy offers the opportunity to treat neurological disorders by a single intervention. READ MORE

  7. 15. Progressive models of Parkinson's disease : behavioural and neurochemical analyses

    Author : Alexandra Alvarsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Parkinson’s disease (PD) is a common neurodegenerative disorder diagnosed based on the presence of motor symptoms, including resting tremor, postural impairment, bradykinesia and rigidity. The pathological hallmarks are degeneration of midbrain dopaminergic neurons and the accumulation of inclusions containing the misfolded protein α-synuclein (termed “Lewy bodies”) throughout the nervous system. READ MORE