Search for dissertations about: "Disease modeling"

Showing result 11 - 15 of 194 swedish dissertations containing the words Disease modeling.

  2. 11. Modeling Amyloid-β Pathology in Alzheimer’s Disease Using the Arctic Mutation

    Author : Ola Philipson; Lars Nilsson; Lars Lannfelt; Fred van Leuven; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; Amyloid; Amyloid-β; intraneuronal; transgenic mice; immunohistochemistry; ELISA; Public health medicine research areas; Folkhälsomedicinska forskningsområden; Geriatrics; Geriatrik;

    Abstract : The Arctic mutation in the Amyloid-β (Aβ) domain of the Amyloid-β precursor protein (APP) causes Alzheimer’s disease (AD) and confers unique biochemical characteristics to Aβ peptides. The aims of this thesis were to evaluate a transgenic model with the Arctic mutation, and to use it to gain new insights into the mechanisms of early (pre-plaque) and late-stage Aβ pathogenesis in AD. READ MORE

  4. 12. Imported infections’ importance : global change driving Dengue dynamics

    Author : Mikkel B. Quam; Joacim Rocklöv; Annelies Wilder-Smith; Eduardo Massad; Dave D. Chadee; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dengue; Zika; Vector-borne Disease; Aedes; Global Change; Climate Change; Viral Evolution; Phylogenetics; Travel; Interconnectivity; Disease Modeling; Madeira; Italy; Japan; Europe;

    Abstract : Background Dengue is a significant problem of international health concern. According to the World Health Organization in 2012, globally, dengue is “the most important mosquito borne viral disease” with incidence 30 higher than it had been 50 years ago. READ MORE

  5. 13. Integrative Modeling of Epigenetic Regulation in Human Disease

    Author : Xi Lu; Xingqi Chen; Chandrasekhar Kanduri; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma; Cross-species; Glioblastoma stem cell; Dravet syndrome; ATAC-seq; Single-cell multi-omics technology;

    Abstract : Glioblastoma is the most common and aggressive primary brain tumor. Standard of treatment prove ineffective, leading to tumor recurrence and an average survival rate of 14 months. This treatment resistance is attributed to both inter-tumor and intra-tumor heterogeneity observed across diverse tumor samples and within individual cells. READ MORE

  6. 14. Prevention of type 2 diabetes : modeling the cost-effectiveness of diabetes prevention

    Author : Anne Neumann; Lars Lindholm; Katarina Steen Carlsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 2 diabetes mellitus; prevention; health economics; Markov modeling; risk equations; health-related quality of life; lifestyle modification; pre-diabetic states; cost-effectiveness; Västerbotten Intervention Programme;

    Abstract : Background: Diabetes is a common and costly disease that is expected to continue even to grow in prevalence and health expenditures over the coming decades. Type 2 diabetes is the most common diabetes type and is characterized by insulin resistance and relative insulin deficiency. READ MORE

  7. 15. Molecular epidemiology approach : nested case-control studies in glioma and lymphoid malignancies

    Author : Florentin Späth; Beatrice S. Melin; Carl Wibom; Ann Sofie Johansson; Ingvar Bergdahl; Ola Landgren; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioma; B cell lymphoma; multiple myeloma; risk; repeated samples; prospective longitudinal study; nested case-control study; circulating sEGFR and sERBB2; circulating immune markers and growth factors; marker disease association; disease progression; NSHDS; Janus; linear mixed modeling; epidemiologi; Epidemiology; Oncology; onkologi;

    Abstract : BACKGROUND: Nested case-control studies aim to link molecular markers with a certain outcome. Repeated prediagnostic samples may improve the evaluation of marker-disease associations. However, data regarding the benefit of repeated samples in such studies are sparse. READ MORE