Search for dissertations about: "DntR"

Found 4 swedish dissertations containing the word DntR.

  2. 1. In search of a biosensor for DNT detection : Studies of inducer response and specificity of DntR

    Author : Rosa Lönneborg; Peter Brzezinski; Ray Dixon; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; DntR; transcriptional regulation; gfp; nitro-aromatic compounds; LysR family; LTTR; TNT; DNT; FACS; directed evolution; random mutagenesis; recombination; structure determination; biokemi; Biochemistry;

    Abstract : The primary aim of the work presented in this thesis was to change the inducer specificity of the DntR protein in order to improve the response to DNT. The long-term goal is to use this protein in a biosensor for DNT, a signature compound for detection of the explosive TNT. READ MORE

  4. 2. Adaptive Responses by Transcriptional Regulators to small molecules in Prokaryotes : Structural studies of two bacterial one-component signal transduction systems DntR and HpNikR

    Author : Cyril Dian; Peter Brzezinski; Séan McSweeney; Elisabeth Sauer-Eriksson; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transcription regulator; bacterial biosensor; LysR family; Inducer-binding; nickel-sensing; NikR; signal transduction system; Helicobacter pylori; Biochemistry; Biokemi; biokemi; Biochemistry;

    Abstract : Prokaryotes are continually exposed to variations in their environment. Survival in unstable milieu requires a wide range of transcriptional regulators (TRs) that respond to specific environmental and cellular signals by modulating gene expression and provide an appropriate physiological response to external stimuli. READ MORE

  5. 3. Rational and combinatorial genetic engineering approaches for improved recombinant protein production and purification

    Author : Nina Bandmann; Per-Åke Nygren; Helena Berglund; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Aqueous two-phase system; combinatorial library; expression vector; flow cytometry; fusion tag; partitioning; peptide library; phage display; recombinant proteins; ribosomal binding site; translation initiation; Bioengineering; Bioteknik;

    Abstract : The bacterium Escherichia coli (E. coli) is in many situations an ideal host for production of recombinant proteins, since it generally provides a rapid and economical means to achieve sufficiently high product quantities. READ MORE

  6. 4. Clonal structures and cell interactions in cancer

    Author : Nathanael Andrews; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Despite sharing an identical genome, cells of higher order multicellular organisms display a large degree of phenotypic diversity. This diversity is maintained by a sophisticated regulatory machinery that integrates information from both intrinsic and extrinsic factors, ultimately coordinating the appropriate gene expression. READ MORE