Search for dissertations about: "Docking"
Showing result 6 - 10 of 152 swedish dissertations containing the word Docking.
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6. A multivariate approach to characterization of drug-like molecules, proteins and the interactions between them
Abstract : En sjukdom kan många gånger härledas till en kaskadereaktion mellan proteiner, co-faktorer och substrat. Denna kaskadreaktion blir många gånger målet för att behandla sjukdomen med läkemedel. För att designa nya läkemedelsmoleyler används vanligen datorbaserade verktyg. READ MORE
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7. Deep learning solutions to protein quaternary structure
Abstract : Interactions between proteins are directly involved in most biological processes and are essential for the correct functioning of every form of life. The nature of protein-protein interactions allows functional assemblies of hundreds of protein chains. READ MORE
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8. Architecture and function of the insulin granule secretion machinery
Abstract : Insulin is released into the blood stream to normalize elevated blood glucose, for example after a meal. The hormone is synthesized by β-cells in the endocrine pancreas, and stored in small vesicles, known as secretory granules, until required. When glucose is elevated, these granules undergo regulated exocytosis and thereby secrete the hormone. READ MORE
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9. Applications of Structural Bioinformatics for the Structural Genomics Era
Abstract : Structural bioinformatics deals with the analysis, classification and prediction of three-dimensional structures of biomacromolecules. It is becoming increasingly important as the number of structures is growing rapidly. READ MORE
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10. Probing Ligand Binding Mechanisms in Insulin-Regulated Aminopeptidases : Computational analysis and free energy calculations of binding modes
Abstract : In recent years insulin-regulated aminopeptidase (IRAP) has emerged as a new therapeutic target for the treatment of Alzheimer’s disease and other memory-related disorders. So far, many potent and specific IRAP inhibitors had been disclosed, including peptides, peptidomimetics, and low-molecular-weight sulfonamides. READ MORE