Search for dissertations about: "Dopamine D1 receptors"

Showing result 1 - 5 of 54 swedish dissertations containing the words Dopamine D1 receptors.

  2. 1. The Role of Dopamine-Metabolising Enzymes in Renal Sodium Handling. An Experimental Study in vivo

    Author : Cecilia Odlind; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; dopamine; kidney; sodium; MAO; COMT; rat; mice; RBF; oxygen; renal; L-dopa; DOPAC; entacapone; phenelzine; dopamine receptors; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Physiology; fysiologi;

    Abstract : Dopamine (DA) has been shown to act as an intrarenal natriuretic hormone and defects in the renal DA system have been associated with some forms of hypertension. How the DA activity is upregulated durin- increased sodium intake is, however, unknown. READ MORE

  4. 2. The architecture of the aging brain : functional reorganization, structural changes, and the role of dopamine receptors

    Author : Robin Pedersen; Alireza Salami; Anna Rieckmann; Anders Wåhlin; Lars Nyberg; Roser Sala-Llonch; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; brain architecture; functional connectivity; dopamine; aging; cognition; memory; functional magnetic resonance imaging; positron emission tomography; graph theory; Laplacian eigenmapping; gradient;

    Abstract : Aging is associated with reorganization of functional brain architecture, potentially leading tocognitive decline in older age. However, the mechanisms responsible for alterations in functionalbrain architecture remain poorly understood. READ MORE

  5. 3. Selectivity of dopamine D1 and D2 receptor agonists – A combined computational approach

    Author : Marcus Malo; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; dopamine; agonists; GPCRs; pharmacophore modeling; protein structure modeling; agonist selectivity;

    Abstract : Dopamine (DA) is an endogenous neurotransmitter acting in the central nervous system. DA plays a key role in many vital brain functions such as behavior, cognition, motor activity, learning, and reward. Dopamine receptors belong to the rhodopsin like family of G-protein coupled receptors (GPCRs). READ MORE

  6. 4. Dopamine receptors in the rat brain

    Author : Mi Hillefors-Berglund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Dopamine D2 receptors; Dopamine D3 receptors; Rat; Autoradiography; [3H]7-OH-DPAT; [3H]PD 128907; Caudate-putamen; Subcortical limbic area; Islands of Calleja; CGS 21680; Toluene; Neurotensin; Asphyxia; Aging; Magnesium; GTP;

    Abstract : Dopamine receptors belong to a large superfamily of G protein-coupled receptors and consist of the D1, D2, D3, D4, and D5 receptors. The D2, D3, and D4 receptors belong to the D2 receptor family which is characterized by having a large third cytoplasmic loop and a short C-terminus projecting into the cytosol, and by inhibiting the enzyme adenylyl cyclase. READ MORE

  7. 5. Up-regulation of dopamine D₂ receptors : in vitro and in vivo studies

    Author : Maria Wanderoy; Eliassitet Eriksson; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; neurokemi och neurotoxikologi; Neurochemistry and Neurotoxicology;

    Abstract : In the central nervous system (CNS) dopaminergic and dopaminoceptive neurons have the ability to respond to variations in dopamine levels by for example adjusting their dopamine receptor levels. One of the most well known phenomena in this respect is that long-term blockade of D2 receptors with antipsychotic drugs leads to an increase in striatal D2 receptor density of experimental animals as well as of schizophrenic patients as measured in both post-mortem studies and in vivo positron emission tomography studies of brain. READ MORE