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Showing result 1 - 5 of 46 swedish dissertations matching the above criteria.
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1. Mechanisms controlling midbrain dopaminergic neuron development
Abstract : The degeneration of midbrain dopaminergic (mDA) neurons accounts for some of the main motor symptoms of Parkinson’s disease (PD). Efforts during the last decades have focused on understanding how mDA neurons are generated and maintained with the hope of developing novel stem cell-based replacement therapies. READ MORE
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2. Molecular and cellular characterization of midbrain dopaminergic neuron development
Abstract : Midbrain dopaminergic (mDA) development is a complex yet highly controlled mechanistic process that is conserved across species. The understanding of these molecular details can open windows to new avenues of therapeutic medicine. Parkinson’s disease (PD) is a debilitating neurological disorder that to date has no cure or established cause. READ MORE
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3. Intrinsic and extrinsic factors controlling the differentiation of human midbrain progenitor cells
Abstract : Parkinson's disease (PD) is a common neurodegenerative disorder characterized by motor deficits. Levodopa treatment provides marked symptomatic relief. However, within 5-10 years after the start of Levodopa treatment, most PD patients display a gradual loss of drug efficacy. READ MORE
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4. A long and winding road: Differentiating human embryonic stem cells into dopaminergic neurons
Abstract : Parkinson’s disease is a progressive neurodegenerative disorder. Since the motor manifestations of the disease is associated with the loss of dopaminergic (DAergic) neurons in the substantia nigra pars compacta, cell replacement therapy is a promising approach for treatment. READ MORE
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5. Regulation of midbrain dopaminergic neuron development by Wnts, sFRPs and bHLH proteins
Abstract : Parkinson’s disease (PD) is a chronic neurodegenerative disorder. The main pathology is characterized by progressive degeneration of the dopaminergic (DA) neurons of the substantia nigra leading to loss of striatal dopamine innervation. The knowledge about the fundamental mechanisms behind the degenerative process has been limited. READ MORE