Search for dissertations about: "Dopaminergic Neurons"
Showing result 1 - 5 of 163 swedish dissertations containing the words Dopaminergic Neurons.
-
1. Generation of Dopaminergic Neurons from Human Embryonic Stem Cells
Abstract : Since the first successful derivation of human embryonic stem cells (hESC), rapid progress has been attained in the development of strategies in differentiation of these cells into various neural lineages, with the fundamental objective of using these cells for replacement and repair of damaged neuronal circuits in the central nervous system (CNS). Of particular interest are midbrain dopaminergic (mDA) neurons, which play a central role in regulation of voluntary movement. READ MORE
-
2. Functional and Transcriptional Studies of Human Dopaminergic Neurons
Abstract : Parkinson’s Disease (PD) is the most common movement disorder and second most common neurodegenerative disease. The principal hallmark of the pathology is represented by a loss of mesencephalic Dopaminergic neurons (mesDA) that reside in the Substantia Nigra pars compacta (SNpc). READ MORE
-
3. Direct Conversion of Human Fibroblasts to Induced Neurons
Abstract : During direct cellular reprogramming, forced expression of key transcription factors (TFs) directly converts one terminally differentiated cell type into that of another fate, exemplified in this theses by the conversion of fibroblasts into functional induced neurons (iNs). Direct conversion of mouse fibroblasts to functional neurons was established in 2010, and the starting point of my doctoral thesis was the aim to transfer iN-technology to human cells and to explore the potential of this technique in regards to generate subtype-specific neurons as well as to use these cells for transplantation studies. READ MORE
-
4. Cholinergic and dopaminergic aspects of dementia in Parkinson's disease: postmortem neuropathological findings and modeling of cognitive dysfunction in rodents
Abstract : Motor symptoms are currently considered the first clinical hallmark of Parkinson’s disease (PD). They develop as a result of dopamine loss in the striatum, subsequent to the progressive neurodegeneration of dopamin- ergic neurons in the substantia nigra. READ MORE
-
5. On dopamine neurons : nerve fiber outgrowth and L-DOPA effects
Abstract : Parkinson’s disease is a disorder mainly characterized by progressive degeneration of dopamine producing neurons in the substantia nigra of the midbrain. The most commonly used treatment strategy is to pharmacologically restore the lost function by the administration of the dopaminergic precursor L-DOPA. READ MORE