Search for dissertations about: "Dopaminergic loss"
Showing result 1 - 5 of 67 swedish dissertations containing the words Dopaminergic loss.
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1. Generation of Dopaminergic Neurons from Human Embryonic Stem Cells
Abstract : Since the first successful derivation of human embryonic stem cells (hESC), rapid progress has been attained in the development of strategies in differentiation of these cells into various neural lineages, with the fundamental objective of using these cells for replacement and repair of damaged neuronal circuits in the central nervous system (CNS). Of particular interest are midbrain dopaminergic (mDA) neurons, which play a central role in regulation of voluntary movement. READ MORE
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2. Functional and Transcriptional Studies of Human Dopaminergic Neurons
Abstract : Parkinson’s Disease (PD) is the most common movement disorder and second most common neurodegenerative disease. The principal hallmark of the pathology is represented by a loss of mesencephalic Dopaminergic neurons (mesDA) that reside in the Substantia Nigra pars compacta (SNpc). READ MORE
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3. Intrinsic and extrinsic factors controlling the differentiation of human midbrain progenitor cells
Abstract : Parkinson's disease (PD) is a common neurodegenerative disorder characterized by motor deficits. Levodopa treatment provides marked symptomatic relief. However, within 5-10 years after the start of Levodopa treatment, most PD patients display a gradual loss of drug efficacy. READ MORE
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4. A long and winding road: Differentiating human embryonic stem cells into dopaminergic neurons
Abstract : Parkinson’s disease is a progressive neurodegenerative disorder. Since the motor manifestations of the disease is associated with the loss of dopaminergic (DAergic) neurons in the substantia nigra pars compacta, cell replacement therapy is a promising approach for treatment. READ MORE
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5. Mechanisms controlling midbrain dopaminergic neuron development
Abstract : The degeneration of midbrain dopaminergic (mDA) neurons accounts for some of the main motor symptoms of Parkinson’s disease (PD). Efforts during the last decades have focused on understanding how mDA neurons are generated and maintained with the hope of developing novel stem cell-based replacement therapies. READ MORE