Search for dissertations about: "Dose prediction"
Showing result 1 - 5 of 90 swedish dissertations containing the words Dose prediction.
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1. On the Prediction of Warfarin Dose
Abstract : Warfarin is one of the most widely used anticoagulants in the world. Treatment is complicated by a large inter-individual variation in the dose needed to reach adequate levels of anticoagulation i.e. INR 2. READ MORE
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2. Pharmacometric Investigations of Prediction Precision and Advances of Models for Composite Scale Data
Abstract : Clinical trials are needed to evaluate new treatments. In late-stage clinical trials, failures are mostly due to lack of efficacy. Fit-for-purpose analysis methods will likely increase the success rates and advance drug development by providing higher precision to support decisions such as go/no-go, dose selection, or sample size. READ MORE
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3. Towards improved oncological treatment of esophageal and gastric cancer. Clinical and translational studies
Abstract : BackgroundThe overall aim of this thesis was to improve the oncological treatment strategies in esophageal and gastric adenocarcinoma (EGAC). Podocalyxin-like protein 1 (PODXL) has been associated with poor prognosis in other cancers and we wanted to investigate its potential role as a prognostic and predictive biomarker in resectable EGAC. READ MORE
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4. Prediction Models and Pharmacogenomics in Adult Growth Hormone Deficiency
Abstract : The overall aim of this thesis was to study clinical and genetic factors that influence response to growth hormone replacement therapy (GHRT) in GH deficient (GHD) adults. The patients were part of a cohort of adults with hypopituitarism and severe GHD who were studied before and after 12 months of GHRT. READ MORE
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5. On Quality in Radiotherapy Treatment Plan Optimisation
Abstract : Radiotherapy is one of the essential treatments used in the fight against cancer. The goal of radiotherapy is to deliver a high dose of ionising radiation to the tumour volume and at the same time minimise the effect on healthy tissue by reducing the radiation to critical organs. READ MORE