Search for dissertations about: "Dose-Rate"

Showing result 1 - 5 of 58 swedish dissertations containing the word Dose-Rate.

2. 1. Biomarkers of ionising radiation relevant to carcinogenesis : Dose, dose rate and LET dependency of the responses

   Author : Milagrosa López Riego; Andrzej Wojcik; Lovisa Lundholm; Alexandros G. Georgakilas; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ionising radiation; low dose; low dose rate; linear energy transfer LET ; mixed beams; dose and dose rate effectiveness factor DDREF ; cancer; DNA damage response; biomarkers; molekylär biovetenskap; Molecular Bioscience;

   Abstract : A better understanding of the relationship between ionising radiation (IR) dose, dose rate and radiation quality, and the risk of stochastic effects would improve risk extrapolation from atomic bomb survivors’ data. Owing to insufficient statistical power of epidemiological studies to detect excess incidence of cancer following low doses of IR delivered at low dose rates (LDLDR), as typically encountered in most common human exposure scenarios, radiobiological experiments are fundamental to describe the biological effectiveness of LDLDR and to define the underlying molecular mechanisms. READ MORE

4. 2. Short and long-term effects of exposure to low dose and low dose rate of gamma radiation : using in vitro and in vivo models

   Author : Traimate Sangsuwan; Siamak Haghdoost; Eva Forssell-Aronsson; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Low dose; Low dose rate; High dose rate; Ionizing radiation; Adaptive response; Senescence; Premature senescence; Oxidative stress; Drosophila embryo; Mutation; DNA repair; molekylär biovetenskap; Molecular Bioscience;

   Abstract : Assessment of human health risks from exposure to ionizing radiation (IR) is mainly based on the extrapolation of results from epidemiological studies on populations exposed to relatively high doses and often at high dose rates (HDR). Risk estimates after exposure to low doses and in particular at low dose rates (LDR) remain controversial due to a lack of epidemiological evidence. READ MORE

5. 3. Dose Escalation with High Dose Rate Brachytherapy or Protons in Curative Radiotherapy of Prostate Cancer

   Author : Lennart Åström; Lars Holmberg; Gunilla Enblad; Henrik Grönberg; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; radiotherapy; brachytherapy; high dose rate; protons; PSA bounce;

   Abstract : The aim of the thesis was to study the outcome and side effects after dose-escalated radiotherapy with high dose rate brachytherapy (HDR-BT) or proton beam therapy (PBT) boost in prostate cancer.The first cohorts of men in Sweden treated with either HDR-BT or PBT in combination with conventional photon beam therapy (2 Gray (Gy) fractions to 50 Gy) were analysed. READ MORE

6. 4. Radiotherapy in a FLASH : Towards clinical translation of ultra-high dose rate electron therapy

   Author : Elise Konradsson; Lund Medicinsk strålningsfysik; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Radiotherapy; Dosimetry; Ultra-high dose rate; Electron therapy; FLASH; Fysicumarkivet A:2023:Konradsson;

   Abstract : FLASH radiotherapy (FLASH-RT) is a promising new approach to radiotherapy that has the potential to transform the field. By administering radiation at ultra-high dose rates (UHDR) on a millisecond timescale, FLASH-RT may increase normal tissue tolerance compared to conventional radiotherapy while maintaining the anti-tumoral effect. READ MORE

7. 5. Investigation of radiation-induced genetic and epigeneticeffects using cultured cells and Drosophila as experimental models: with focus on dose rate

   Author : Traimate Sangsuwan; Siamak Haghdoost; Ulrich Theopold; Stenerlöw Bo; David Berger; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Gamma radiation; low-dose-rate; MTH1; MYH; mutant frequency; Drosophila milanogaster; embryogenesis; mutation; molekylär biovetenskap; Molecular Bioscience;

   Abstract : .... READ MORE