Search for dissertations about: "Dose-response relationships"

Showing result 1 - 5 of 36 swedish dissertations containing the words Dose-response relationships.

  2. 1. DNA Damage Response of Normal Epidermis in the Clinical Setting of Fractionated Radiotherapy : Evidence of a preserved low-dose hypersensitivity response

    Author : Fredrik Qvarnström; Ingela Turesson; Gunilla Enblad; Mats Harms-Ringdahl; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA damage response; low-dose hypersensitivity; dose response; normal tissue; epidermis; keratinocyte; fractionated radiotherapy; DNA double strand break; DSB; foci; γH2AX; 53BP1; checkpoint; p21; apoptosis; mitosis; Oncology; Onkologi; Oncology; onkologi;

    Abstract : Investigations of DNA damage response (DDR) mechanisms in normal tissues have implications for both cancer prevention and treatments. The accumulating knowledge about protein function and molecular markers makes it possible to directly trace and interpret cellular DDR in a tissue context. READ MORE

  4. 2. Transcriptional biomarkers of toxicity – powerful tools or random noise? : An applied perspective from studies on bivalves

    Author : Gustaf Magnus Oskar Ekelund Ugge; Olof Berglund; Annie Jonsson; Helena Westerdahl; Mikael Ejdebäck; Bruno Nunes; Högskolan i Skövde; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biomarkers; Bivalves; Bivalvia; Ecotoxicology; Environmental toxicology; Environmental risk assessment; RT-qPCR; qPCR; Quantitative PCR; Systematic review; Meta-analysis; Dose-response relationships; Concentration-response relationships; Heavy metals; Metals; General toxicity; Copper; Duck mussel; Anodonta anatina; Freshwater; Gene transcription; Biomarkörer; Musslor; Bivalvia; Ekotoxikologi; Miljötoxikologi; Miljöriskbedömning; RT-qPCR; qPCR; Kvantitativ PCR; Systematic review; Metaanalys; Dos-responssamband; Koncentration-responssamband; Tungmetaller; Metaller; Allmän toxicitet; Koppar; Allmän dammussla; Anodonta anatina; Sötvatten; Gentranskription; Ekologisk modellering; Ecological Modelling Group; Biomarkörer; Musslor; Bivalvia; Ekotoxikologi; Miljötoxikologi; Miljöriskbedömning; RT-qPCR; qPCR; Kvantitativ PCR; Systematic review; Metaanalys; Dos-responssamband; Koncentration-responssamband; Tungmetaller; Metaller; Allmän toxicitet; Koppar; Allmän dammussla; Anodonta anatina; Sötvaten; Gentranskription; Biomarkers; Bivalves; Ecotoxicology; Environmental toxicology; Environmental risk assessment; Quantitative PCR; Meta-analysis; Dose-response relationships; Concentration-response relationships; Heavy metals; Metals; General toxicity; Copper; Duck mussel; Freshwater; Gene transcription;

    Abstract : Aquatic organisms are constantly at risk of being exposed to potentially harmful chemical compounds of natural or anthropogenic origin. Biological life can for instance respond to chemical stressors by changes in gene expression, and thus, certain gene transcripts can potentially function as biomarkers, i.e. READ MORE

  5. 3. Cause-Specific Mortality and Physical Fitness in Mental Disorders - Epidemiological and Internventional Studies

    Author : Malin Henriksson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mental disorders; Anxiety Disorders; Physical fitness; Exercise; Intervention Studies; Primary Health Care; Dose-response; Randomized Controlled Trial;

    Abstract : Mental illnesses are common and constitute a substantial health-related and financial burden on both the individual and society. Mental disorders in general have increased risk of somatic morbidity. An early age of onset is commonly seen in anxiety disorders and the prevalence of these disorders has increased in youth in recent years. READ MORE

  6. 4. Bone and kidney effects from cadmium exposure : dose effect and dose response relationships

    Author : Tobias Alfvén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Bone; bone mineral density; cadmium; epidemiology; environmental exposure; fractures; heavy metals; human; kidneys; occupationally exposure; osteoporosis; protein HC; tubular proteinuria;

    Abstract : Cadmium is a heavy metal that has been dispersed in the environment during the last century due to human activity. It is well known that high cadmium exposure causes renal damage and in severe cases also osteoporosis and osteomalacia. Osteoporosis is a major cause of morbidity worldwide. READ MORE

  7. 5. Dose-response modeling : evaluation, application, and development of procedures for benchmark dose analysis in health risk assessment of chemical substances

    Author : Salomon Sand; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Risk assessment; dose-response; benchmark; BMD;

    Abstract : In this thesis, dose-response modeling and procedures for benchmark dose (BMD) analysis in health risk assessment of chemical substances have been investigated. The BMD method has been proposed as an alternative to the NOAEL (no-observedadverse- effect-level) approach in health risk assessment of non-genotoxic agents. READ MORE