Search for dissertations about: "Downstream processing"

Showing result 11 - 15 of 97 swedish dissertations containing the words Downstream processing.

  2. 11. Mille-feuille Filter : A Non-woven Nano-cellulose Based Virus Removal Filter for Bioprocessing

    Author : Simon Gustafsson; Albert Mihranyan; Jonas Lindh; Kurt Brorson; Uppsala universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; virus filtration; mille-feuille; downstream; nanocellulose; protein throughput; protein recovery; LRV; MVM; Cladophora; non-woven filter;

    Abstract : Virus removal filters, produced from synthetic surface-modified polymers or regenerated cellulose by phase inversion, are vital to the production of therapeutic proteins such as monoclonal antibodies and plasma proteins. Use of these filters is also one of the most expensive purification steps in the downstream processing of proteins due to high sales price and being limited to a single use. READ MORE

  4. 12. Influence of Escherichia coli feedstock properties on the performance of primary protein purification

    Author : Mattias Råvik; Andres Veide; Åsa Emmer; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Downstream processing; cell surface properties; surface plasmon resonance; contact angle measurements; microelectrophoresis; aqueous two-phase partitioning; filtration; EBA adsorbents; high-pressure homogenisation; Biochemistry; Biokemi;

    Abstract : Abstract The aim of the present study was to increase the understanding of how the cell surface properties affect the performance of unit operations used in primary protein purification. In particular, the purpose was to develop, set up and apply methods for studies of cell surface properties and cell interactions. READ MORE

  5. 13. Primary Recovery of Biologically Active Compounds Using Macroporous Monolithic Hydrogels

    Author : Amro Hanora; Bioteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Downstream processing; macroporous; Biologically active compounds; Biotechnology; Läkemedelsteknik och relaterad teknik; Pharmaceutical and related technologies; Polymerteknik; biopolymers; Biokemisk teknik; Polymer technology; Makromolekylär kemi; Biochemical technology; Affinity chromatography; Ion exchange chromatography; Expanded bed adsorption chromatography.; Macromolecular chemistry; High through put screening; lactica acids; Endotoxin; Plasmid DNA; Cryogel columns; Bioteknik;

    Abstract : The completion of sequencing of human and other mammalian genomes opens a new era for drug development. New approaches have been proposed for tackling diseases such as development of small molecule therapies based on understanding of human genome and proteome, new proteinous based therapies, where the therapeutic protein can inhibit or modify a certain metabolic pathway or DNA-based therapies delivering a gene into the cell (e. READ MORE

  6. 14. The cellular processing of the endocannabinoid anandamide and its pharmacological manipulation

    Author : Lina Thors; Christopher J Fowler; David A Kendall; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocannabinoid; anandamide; cellular processing; pain; flavonoids; fatty acid amide hydrolase; Pharmacology; Farmakologi; medicinsk farmakologi; Medical Pharmacology;

    Abstract : Anandamide (arachidonoyl ethanolamide, AEA) and 2-arachidonoyl glycerol (2-AG) exert most of their actions by binding to cannabinoid receptors. The effects of the endocannabinoids are short-lived due to rapid cellular accumulation and metabolism, for AEA, primarily by the enzymes fatty acid amide hydrolase (FAAH). READ MORE

  7. 15. Resource efficient automatic segmentation of medical images

    Author : Minh Hoang Vu; Tommy Löfstedt; Tufve Nyholm; Anders Garpebring; Joakim Jonsson; Örjan Smedby; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; radiotherapy; medical imaging; deep learning; convolutional neural network; generative adversarial network; data augmentation; semantic segmentation; classification; activation map compression; radiofysik; radiation physics;

    Abstract : Cancer is one of the leading causes of death worldwide. In 2020, there were around 10 million cancer deaths and nearly 20 million new cancer cases in the world. Radiation therapy is essential in cancer treatments because half of the cancer patients receive radiation therapy at some point. READ MORE