Search for dissertations about: "Downstream processing"

Showing result 6 - 10 of 97 swedish dissertations containing the words Downstream processing.

  2. 6. Developing integrated downstream processes for next-generation biologics

    Author : Anton Löfgren; Avdelningen för kemiteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Downstream processing; Preparative chromatography; Optimization; Integration;

    Abstract : Manufacturing of biopharmaceuticals is a costly and time consuming process due to its inherent complexity and variability. The downstream process is the most expensive part and it involves multiple non-trivial steps. Continuous integrated manufacturing is a new concept that is encouraged by authorities. READ MORE

  4. 7. Monitoring of product variants in biopharmaceutical downstream processing : Mechanistic and data-driven modeling approaches

    Author : Patricia Roch; Carl-Fredrik Mandenius; Gunnar Hörnsten; Franciscus van der Berg; Linköpings universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Abstract : During the manufacturing of biopharmaceuticals, a multistep purification strategy is employed to remove process-related impurities and product variants, to achieve high product quality, assuring patients’ safety. To guarantee that biopharmaceuticals are safe and to accomplish quality, strict policies were established by regulatory agencies as well as guiding principles, such as Quality by Design and process analytical technology. READ MORE

  5. 8. Cryogels as Solid Supports in Bioprocessing

    Author : Gry Jespersen; Bioteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Downstream processing; cryogel; solid support; biomacromolecules; chromatography;

    Abstract : In recent years the market for biopharmaceutical products has been increasing rapidly as a result of an increased demand for new and efficient treatments of various indications. Biopharmaceuticals are distinguished from chemical drugs by being derived from a biological origin and are hence, frequently constituting biological macromolecules. READ MORE

  6. 9. Design and Control of Integrated Continuous Processes for the Purification of Biopharmaceuticals

    Author : Joaquin Gomis Fons; Avdelningen för kemiteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Integrated Continuous Biomanufacturing; Downstream Processing; Process Design and Optimization; Process Control; Biopharmaceuticals;

    Abstract : The production of biopharmaceuticals so far has been based on batch processes that are robust and well-known, but very inefficient and inflexible, causing the products to be very expensive and process development to be slow and costly. The production of biopharmaceuticals is thus changing towards integrated continuous biomanufacturing (ICB) in order to reduce costs and increase flexibility in a constantly changing market. READ MORE

  7. 10. Normalization and analysis of high-dimensional genomics data

    Author : Mattias Landfors; Patrik Rydén; Rebecka Jörnsten; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; normalization; pre-processing; microarray; downstream analysis; evaluation; sensitivity; bias; genomics data; gene expression; spike-in data; ChIP-chip; Mathematical Statistics; matematisk statistik;

    Abstract : In the middle of the 1990’s the microarray technology was introduced. The technology allowed for genome wide analysis of gene expression in one experiment. Since its introduction similar high through-put methods have been developed in other fields of molecular biology. READ MORE