Search for dissertations about: "Drug discovery"

Showing result 1 - 5 of 204 swedish dissertations containing the words Drug discovery.

  1. 1. Studies of Retroviral Reverse Transcriptase and Flaviviral Protease Enzymes as Antiviral Drug Targets Applications in Antiviral Drug Discovery & Therapy

    University dissertation from Acta Universitatis Upsaliensis : Uppsala universitet

    Author : Muhammad Junaid; Uppsala universitet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virus; enzymes; HIV AIDS; retroviral reverse transcriptase; flaviviral protease; NRTIs; proteochemometrics; drug resistance; DEN; JEV; NS2B H -NS3pro; antiviral; drug targets; drug discovery; drug therapy.; Farmakologi; Pharmacology;

    Abstract : Viruses are a major threat to humans due to their unique adaptability, evolvability and  capability to control their hosts as parasites and genetic elements. HIV/AIDS is the third largest cause of death by infectious diseases in the world, and drug resistance due to the viral mutations is still the leading cause of treatment failure. READ MORE

  2. 2. The G protein-coupled receptor GPR30 signalosome - A novel G protein-independent mechanism regulating cAMP signaling and receptor trafficking

    University dissertation from Drug Target Discovery

    Author : Stefan Broselid; Lunds universitet.; Lund University.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AKAP5; AKAP; MAGUK; cAMP signaling; constitutive signaling; signalosome; GPER; GPR30; GPCR; cytokeratin; RAMP3; apoptotic signaling; breast cancer; PDZ; PDZ-ligand;

    Abstract : Popular Abstract in Swedish Den här avhandlingen handlar om ett protein, en receptor, kallad GPR30. GPR30 tillhör proteinfamiljen G protein-kopplade receptorer vilka är nödvändiga för att celler ska kunna kommunicera med varandra och med sin omgivning. READ MORE

  3. 3. Drug discovery against leishmaniasis Bio- and chemoinformatic guided strategies for target evaluation and hit identification

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Elisabet Vikeved; Uppsala universitet.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Leishmaniasis; Drug discovery; Lateral gene transfer; Comparative genomics; Virtual screening; Target fishing; Marine natural products;

    Abstract : Leishmaniasis is a neglected tropical disease mainly affecting poor people in developing countries. It is caused by infections of flagellated protozoa belonging to genus Leishmania. The few available drugs are associated with problems such as low effectiveness, severe side effects and resistance development. READ MORE

  4. 4. Interaction Studies of Secreted Aspartic Proteases (Saps) from Candida albicans Application for Drug Discovery

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Dan Backman; Uppsala universitet.; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; SPR Biosensor; Secreted aspartic proteases; Candida albicans; interaction kinetics; drug discovery; protease inhibitor; Biokemi; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi;

    Abstract : This thesis is focused on enzymatic studies of the secreted aspartic proteases (Saps) from Candida albicans as a tool for discovery of anti-candida drugs. C. albicans causes infections in a number of different locations, which differ widely in the protein substrates available and pH. Since C. READ MORE

  5. 5. Microdialysis to study the Gastrin-ECL cell Axis in the conscious rat

    University dissertation from Peter Ericsson, Department of Experimental Medical Science, Drug Target Discovery

    Author : Peter Ericsson; Lunds universitet.; Lund University.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The ECL cells constitute the major endocrine cell population in the acid-producing part of the stomach. Gastrin from G cells in the antrum is the main stimulus of gastric acid secretion. Gastrin stimulates the ECL cells in the oxyntic mucosa to mobilize histamine, which in turn stimulates the parietal cells to produce hydrochloric acid. READ MORE