Search for dissertations about: "Drug resistance TB"

Showing result 1 - 5 of 29 swedish dissertations containing the words Drug resistance TB.

2. 1. Pharmacokinetic, efficacy and safety modeling of new treatments against drug-resistant tuberculosis

   Author : Lénaïg Tanneau; Mats Karlsson; Elin Svensson; Italo Poggesi; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; pharmacometrics; nonlinear mixed effect models; tuberculosis; drug-resistance; bedaquiline; delamanid; metabolite; drug-drug interactions; QTc interval; transaminases; time-to-positivity; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Tuberculosis (TB) is an ancient infectious disease that remains one of the greatest killers on the planet. Its eradication is impeded by the development of resistance to first-line treatment. Each year half a million patients are infected with drug-resistant (DR) TB. READ MORE

4. 2. Drug resistance in mycobacterium tuberculosis

   Author : Getahun Abate; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Multidrug-resistance; tuberculosis; cefepime; moxicillin-clavulanate; ethambutol; WIT; rifampicin; isoniazid; katG;

   Abstract : Drug-resistant tuberculosis is a global public health problem. This investigation was performed to find ways of improving regimens that could be used for the treatment of drug- and multidrug-resistant TB and also to find a rapid method of diagnosis of drug resistant TB, particularly MDR-TB. Among 107 isolates of M. READ MORE

5. 3. Drug-resistance in M. tuberculosis and the characterisation of a new anti-tuberculosis drug-candidate

   Author : Emma Huitric; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The occurrence of multidrug-resistant (MDR) tuberculosis (TB) has been increasing at alarming levels globally, and the spread of extensively drug-resistant (XDR) M. tuberculosis is threatening the control of tuberculosis. READ MORE

6. 4. Drug-resistant Mycobacterium tuberculosis in Estonia

   Author : Annika Krüüner; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Tuberculosis; Estonia; M. tuberculosis; drug resistance; MDR-TB; Beijing genotype; cross-resistance; kanamycin; amikacin; rrs mutations; 16S rRNA; exposure; nosocomial transmission; mycobacterial persistence; re-infection; DST; second-line drugs; Bactec; 460; DNA fingerprinting; spoligotyping;

   Abstract : Tuberculosis (TB) infection and disease patterns among different populations are extremely heterogeneous. This thesis explores mainly by microbiological methods the epidemiology of TB in Estonia. Through the work high rates of drug resistance were found. READ MORE

7. 5. Rapid detection of drug resistance and genetic characterisation of Mycobacterium tuberculosis isolates in Honduras

   Author : Senia Rosales; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Background: New challenges for tuberculosis (TB) control are emerging in the 21st century. The deadly combination TB/HIV as well as the development and spread of new forms of drug resistance are some examples. In this context, the timely detection of TB cases, especially of those with resistant TB is important. READ MORE