Search for dissertations about: "Drug safety"

Showing result 21 - 25 of 157 swedish dissertations containing the words Drug safety.

  2. 21. Pharmacoepidemiologic studies of drug safety in pediatric chronic inflammatory disease

    Author : Viktor Wintzell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Safety evidence for use of pharmaceutical drugs in children, including treatments for serious conditions such as chronic inflammatory diseases, is generally scarce. Off-label use is common and clinicians need to rely on evidence from adults when prescribing to children. READ MORE

  4. 22. 3D Printed scaffolds as cancer microenvironment medels for drug discovery

    Author : Jennifer Rosendahl; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 3D Printing; Breast cancer; Biomaterials; Drug development;

    Abstract : Cancer is one of the most common diseases in the modern world and major efforts are made globally to develop new diagnostics and treatments. It originates from a cell which, at some point, has begun to divide and grow uncontrollably. The most common type is breast cancer, and like all other cancers there is a need of more efficient drug therapies. READ MORE

  5. 23. Nonlinear Modeling and Feedback Control of Drug Delivery in Anesthesia

    Author : Margarida M. Silva; Alexander Medvedev; Teresa Mendonça; Torbjörn Wigren; Robain De Keyser; Uppsala universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; anesthesia; drug delivery; feedback control; nonlinear modeling; pharmacokinetics pharmacodynamics; PID control; system identification; Wiener model; Elektroteknik med inriktning mot reglerteknik; Electrical Engineering with specialization in Automatic Control;

    Abstract : General anesthesia is a drug-induced reversible state where neuromuscular blockade (NMB), hypnosis, and analgesia (jointly denoted by depth of anesthesia - DoA) are guaranteed. This thesis concerns mathematical modeling and feedback control of the effect of the muscle relaxants atracurium and rocuronium, the hypnotic propofol, and the analgesic remifentanil. READ MORE

  6. 24. Pain relief following cesarean section : short and long term perspectives

    Author : Boel Niklasson; Agneta Blanck; Märta Segerdahl; Susanne Georgsson Öhman; Sophiahemmet Högskola; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pain management; Local anesthesia; Cesarean section; Morphine consumption; Postoperative pain; Persistent pain; Risk factors; Quality of daily life; Multimodal treatment; Oxycodone; Codeine; Newborn; Safety; pain management;

    Abstract : BackgroundPostoperative pain treatment in women undergoing cesarean section (CS) needs to be effective to enable fast and smooth recovery without adverse outcomes and to improve breastfeeding and bonding between mother and child. It is also important that pain treatment should have minimal impact on the newborn. READ MORE

  7. 25. Tryptophan-related Neurotransmission in the Brain: Disturbances Associated with Experimental Hepatic Encephalopathy

    Author : Peter B F Bergqvist; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tetrodotoxin; serotonin; release; rat; quinolinic acid; potassium; chloroamphetamine; noradrenaline; neurotransmission; microdialysis; hepatic encephalopathy; fenfluramine; drug safety; dopamine; coma; citalopram; ammonia; calcium; brain; tryptophan; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Abstract : In the present study, L-tryptophan (TRP)-related disturbances in the brain in experimental hepatic encephalopathy (HE) were investigated. The endogenous NMDA-receptor agonist and L-TRP metabolite quinolinic acid (QUIN) has been suggested to be involved in the pathogenesis of HE. READ MORE