Search for dissertations about: "Drug use"

Showing result 1 - 5 of 928 swedish dissertations containing the words Drug use.

  1. 1. Characterization of parameters influencing intracellular bioavailability and prediction of intracellular drug exposure

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Andrea Treyer; Uppsala universitet.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intracellular drug bioavailability; unbound drug concentration; drug disposition; ADME; drug transport; drug metabolism membrane partitioning; phospholipid; drug-drug interaction; antisense oligonucleotide; cell-penetrating peptide; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : This thesis work investigates factors influencing intracellular drug disposition. An experimental method for measurement of intracellular bioavailability (Fic), was used throughout. Fic is defined as the ratio between the unbound drug concentration inside the cell and the compound concentration in the cell exterior. READ MORE

  2. 2. Psychoactive prescription drug use disorders, misuse and abuse Pharmacoepidemiological aspects

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Micaela Tjäderborn; Linköpings universitet.; Linköpings universitet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Psychoactive prescription drugs; psychotropic drugs; prescription drug use disorders; prescription drug misuse; abuse; pharmacovigilance; drug utilization; pharmacoepidemiology;

    Abstract : Background: There is a widespread and increasing use of psychoactive prescription drugs, such as opioid analgesics, anxiolytics, hypnotics and anti-epileptics, but their use is associated with a risk of drug use disorder, misuse and abuse. Today, these are globally recognized and emerging public health concerns. READ MORE

  3. 3. Hazards of Drug Therapy On the Management of Adverse Drug Reactions: From Signal Detection and Evaluation to Risk Minimization

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Karin Hedenmalm; Uppsala universitet.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; adverse drug reactions; spontaneous reporting systems; drug regulation; pharmacovigilance; incidence; Farmakologi; MEDICINE Physiology and pharmacology Pharmacological research; MEDICIN Fysiologi och farmakologi Farmakologisk forskning;

    Abstract : Spontaneous reporting systems (SRSs) for adverse drug reactions (ADRs) have been developed as a result of the thalidomide disaster, whereby thousands of children world-wide were born with birth defects. The Swedish Adverse Drug Reactions Advisory Committee was established in 1965. READ MORE

  4. 4. Drug Eluting Hydrogels Design, Synthesis and Evaluation

    University dissertation from University of Cape Town

    Author : Lage Ahrenstedt; [2012]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Drug delivery; PEGylation; Rapamycin; Dexamethasone; Controlled release; Hydrogels; Slow release;

    Abstract : Hydrogels have successfully proved themselves useful for drug delivery applications and several delivery routes have been developed over the years. The particular interest in this work was to design, synthesise and evaluate in situ forming drug eluting hydrogels, which have the potential to ameliorate the healing of cardiovascular diseases. READ MORE

  5. 5. Submicron Calcium Phosphate Spheres for Biomedical Applications Synthesis and Use

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Tao Qin; Uppsala universitet.; [2016]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; calcium phosphate; spheres; dentinal hypersensitivity; drug release; tooth bleaching;

    Abstract : Calcium phosphate spheres as biomaterials have been attracting attention in recent years. Calcium phosphate occurs naturally in bone, and a hollow structure could be advantageous for drug loading and release. READ MORE