Search for dissertations about: "Drug-Resistance"

Showing result 1 - 5 of 203 swedish dissertations containing the word Drug-Resistance.

  1. 1. Circumventing drug resistance : Studies exploring the expediency of a total cell kill chemoresistance assay

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Bertil Jonsson; Uppsala universitet.; [1998]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical sciences; drug resistance; drug resistance assay; clinical correlations; cancer; human; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Abstract : Cellular resistance to anti-cancer drugs is considered to be the major cause of treatment failure in clinical practice. The present studies have therefore focused on ways to circumvent resistance as evaluated by an in vitro chemoresistance assay. READ MORE

  2. 2. Heterogeneity of leukemic cells with regard to daunorubicin accumulation and efflux : potential role in drug resistance

    University dissertation from Linköping : Linköping University

    Author : Eva Knaust; Linköpings universitet.; Linköpings universitet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drug resi stance. acute myeloid leukemia; flow cytometry; gene expression; transport kinetics; apoptosis; MEDICINE; MEDICIN;

    Abstract : Cellular resistance to chemotherapy is a major cause of treatment failure in acute myelocytic leukemia (AML) and other malignancies. Drug resistance is multifactorial; the most studied mechanism being multidrug resistance (MDR), mediated by the P-glycoprotein (PPG), a transmembrane transport protein with a pump function, encoded by the mdr 1 gene. READ MORE

  3. 3. Drug resistance in mycobacterium tuberculosis

    University dissertation from Stockholm : Karolinska Institutet, Microbiology and Tumor Biology Center (MTC)

    Author : Getahun Abate; Karolinska Institutet.; Karolinska Institutet.; [1999]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multidrug-resistance; tuberculosis; cefepime; moxicillin-clavulanate; ethambutol; WIT; rifampicin; isoniazid; katG;

    Abstract : Drug-resistant tuberculosis is a global public health problem. This investigation was performed to find ways of improving regimens that could be used for the treatment of drug- and multidrug-resistant TB and also to find a rapid method of diagnosis of drug resistant TB, particularly MDR-TB. Among 107 isolates of M. READ MORE

  4. 4. Biological markers in breast cancer and acute leukaemia with focus on drug resistance

    University dissertation from Örebro : Örebro universitet

    Author : Elisabet Tina; Örebro universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; acute leukaemia; drug resistance; toposiomerase IIa; BCRP; HER2; SLC25A43; flow cytometry; real time PCR; whole genome screening; MEDICINE; MEDICIN; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi; Biomedicin; Biomedicine;

    Abstract : .... READ MORE

  5. 5. Studies of drug resistance in minor HIV quasispecies

    University dissertation from Stockholm : Karolinska Institutet, Dept of Laboratory Medicine

    Author : Halime Ekici; Karolinska Institutet.; Karolinska Institutet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The main objective was to study drug resistance mutations (DRM) in the HIV-1 reverse transcriptase (RT) gene of minor HIV-1 quasispecies, not detectable with standard techniques. Sensitive allele-specific PCR (AS- PCR) and next-generation sequencing (NGS) were developed to study resistance to drugs of relevance in low- and middle-income countries (LMIC); the nucleoside analogue RT inhibitor (NRTI) lamivudine (3TC) and the non-nucleoside RT inhibitors (NNRTIs) efavirenz (EFV) and nevirapine (NVP). READ MORE