Search for dissertations about: "Drug-resistant epilepsy"

Showing result 1 - 5 of 11 swedish dissertations containing the words Drug-resistant epilepsy.

  2. 1. Longitudinal cognitive changes in medically and surgically treated patients with drug resistant partial epilepsy

    Author : Lena Andersson-Roswall; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug resistant partial epilepsy; epilepsy surgery; longitudinal cognitive changes;

    Abstract : When this study was initiated, there were few published longitudinal studies on cognition in medically treated patients with refractory epilepsy, and none included reassessment data from healthy controls. At the time there were no long-term reports on surgically treated epilepsy patients. READ MORE

  4. 2. The role of ABC transporters and inflammation in drug-resistant epilepsy

    Author : Lora Deuitch Weidner; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis explores two pathologies thought to be related to drug resistance in epilepsy that may themselves be causally related: 1) overexpression of drug transporters in capillaries and 2) inflammation. With regard to the first hypothesis, overexpression of the ATP-binding cassette (ABC) transporters, P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), at the blood-brain barrier are thought to contribute to drug resistance in epilepsy. READ MORE

  5. 3. Source localisation of epileptiform activity in epilepsy of temporal lobe origin

    Author : Göran Lantz; Klinisk neurofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; frequency analysis; ictal; singe photon emission computed tomography; volume conduction; extracranial; intracranial; LORETA; dipole; source localisation; epilepsy; mesolimbic; Fast Fourier Transform; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Abstract : In patients with drug resistant partial epilepsy, who are under consideration for epilepsy surgery, interictal and ictal EEG recorded with extracranial electrodes plays an important role in the localisation of the seizure onset area. During the past years, methods have been developed, which can be used to estimate the location of the source of epileptiform activity in the brain from extracranial EEG data. READ MORE

  6. 4. A pharmacokinetic and pharmacodynamic study of an antiepileptic drug (lamotrigine) in young patients with drug-resistant generalized epilepsy

    Author : Ann-Sofie Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : High-performance liquid chromatography; Antiepileptic drugs; Therapeutic drug monitoring; Lamotrigine; Carbamazepine; Epilepsy; Children; Lennox-Gastaut; Efficacy; CSF; [gamma]aminobuturic acid; Glutamate; Aspartate; Glycine; EEG;

    Abstract : The purpose of the present study was to investigate the safety and efficacy of lamotrigine in young patients with drug-resistant generalised epilepsy. This group of patients is difficult to study due to a high seizure frequency, comorbidity and the frequent use of polytherapy. READ MORE

  7. 5. Advancing gene therapy for epilepsy. Translational pre-clinical studies with neuropeptide Y and glial cell-line derived neurotrophic factor

    Author : Esbjörn Melin; Epilepsicentrum; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epilepsy; Gene Therapy; neuropeptide Y NPY ; Y2 receptor; GDNF; Encapsulated cell biodelivery; seizure; In-vivo;

    Abstract : Epilepsy is a neurological disorder, affecting approximately 1% of the population. The high rate of drug-resistance in epilepsy in general (30%), and temporal lobe epilepsy (TLE) in particular, pose a serious clinical problem. Thus, novel treatments for drug-resistant epilepsy is highly warranted. READ MORE