Search for dissertations about: "Dry Powder Inhaler"

Found 4 swedish dissertations containing the words Dry Powder Inhaler.

2. 1. Powder mechanics and dispersion properties of adhesive mixtures for dry powder inhalers : Conceptualized as a blend state model

   Author : Jonas Rudén; Göran Alderborn; Göran Frenning; Tobias Bramer; Kyrre Thalberg; Regina Scherliess; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inhalation; Dry Powder Inhaler; adhesive mixture; aerosols; powder mechanics; dispersibility; aerosolization; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Inhaled medicines is a therapy that dates back several thousands of years. Nowadays, using various types of inhaler devices to deliver active pharmaceutical ingredients (APIs) to treat respiratory diseases has become common practice. READ MORE

4. 2. Deposition and absorption of inhaled drugs

   Author : Eva Bondesson; Malmö Klinisk fysiologi och nuklearmedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tomografi; radiologi; Klinisk fysiologi; medical instrumentation; tomography; radiology; Clinical physics; technetium-99m; radionuclide imaging; radioactive aerosol; powder inhaler; pharmacokinetics; mucociliary clearance; lung deposition; gamma scintigraphy; inhalation; deposition modelling; drug absorption; absorption enhancer; aerosol; medicinsk instrumentering; Physiology; Fysiologi;

   Abstract : Main objectives of this thesis were to evaluate a gamma scintigraphic method used to quantify drug aerosol deposition in the lung, to investigate the influence of two aerosol inhalation parameters on the distribution of inhaled dry powder within the airways, to assess pulmonary absorption kinetics and bioavailability of an inhaled hydrophilic solute in relation to site of deposition, and to assess the influence of a surface active agent (sodium taurocholate, a bile salt) on the deposition and absorption of an inhaled hydrophilic solute. Repeated planar gamma scintigraphy was found to provide the same information on total pulmonary drug deposition as an independent method that involved assessments of urinary drug recovery after blockage of gastrointestinal drug absorption when all of the critical parts of the methodological procedures were accurately and meticulously executed. READ MORE

5. 3. Understanding Adhesive Mixtures for Inhalation : Particle Dynamics Modelling and Segregation Experiments

   Author : Sohan Sarangi; Göran Frenning; Göran Alderborn; Kyrre Thalberg; Johannes Khinast; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inhalation; adhesive mixtures; dry powder inhaler; discrete element method; segregation; stability; modeling; Galenisk farmaci; Pharmaceutics; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Pulmonary route has been used as a source of drug delivery to lungs for centuries. Drugformulation decides the type of inhaler devices such as pressurized metered-dose inhalers(pMDIs), nebulizers and dry powder inhalers (DPIs). READ MORE

6. 4. Mechanisms of adhesive mixing for drug particle inhalation (Numerical investigation of the interplay between formulation variables)

   Author : Mohammadreza Tamadondar; Chalmers tekniska högskola; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Discrete Element Method; Agglomerate; Carrier Particle; Adhesive mixing; Dispersion; DPI-formulation;

   Abstract : Formulation of therapeutic dry powders for lung drug delivery via inhalation is done via adhesive mixing. In this process, micron-sized active pharmaceutical ingredient particles are blended with relatively coarse carrier particles until stable adhesive units of carrier and drug particles are formed. READ MORE