Search for dissertations about: "Dual Specific Antibodies"

Showing result 1 - 5 of 14 swedish dissertations containing the words Dual Specific Antibodies.

  1. 1. Engineering Antibody Specificity Using Combinatorial Antibody Libraries

    Author : Jenny Boström; [2009]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; antibody Antigen Interactions; Dual Specific Antibodies; Herceptin; Human Epidermal Growth Factor Receptor 2; Thermodynamic Analysis; therapeutic Antibody Engineering; Synthetic Phagedisplayed Antibody Libraries; Vascular Endothelial Growth Factor; Bacterial Display; trastuzumab;

    Abstract : The research presented in this thesis investigates antibody specificity, antibody-antigen and protein-protein interactions using combinatorial antibody libraries, phage-display and bacterial display technology. One goal was to develop a method to generate antibodies that bind two protein antigens with high affinity using a single-antigen binding site, and to investigate the molecular and thermodynamic requirements for antibody multispecificity. READ MORE

  2. 2. Transcriptome and Proteome Analysis using Signature Tags

    University dissertation from Stockholm : Bioteknologi

    Author : Charlotta Agaton; KTH.; [2003]
    Keywords : functional genomics; 3´-end signature tags; pyrosequencing; amplification; PrEST; chromosome 21; polyclonal antibodies; dual expression; affinity purification;

    Abstract : With the full sequence of the human genome now available, anexciting era in biomedical research has started. The sequenceprovides information about all our genes and greatly increasesthe scope to compare genetic activities in different cells, toanalyze genetic variation between individuals and betweendifferent species and, most importantly, to investigatesystematically the whole genome in a gene-by-gene manner, andthus increase our understanding of gene function. READ MORE

  3. 3. Herpes simplex virus infection: epidemiological aspects and analysis of the type-specific antibody response

    University dissertation from Göteborg : Göteborg University

    Author : Petra Tunbäck; Göteborgs universitet.; Gothenburg University.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; herpes simplex virus; first episode genital herpes; seroepidemiology type-specific antibody-response; glycoprotein G-1; epitope-mapping;

    Abstract : Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are ubiquitous viruses, often leading to asymptomatic infections in humans. However, different clinical presentations can be seen including recurrent oral or genital lesions, meningitis and neonatal herpes. READ MORE

  4. 4. Systems enabling antibody-mediated proteomics research

    University dissertation from Stockholm : KTH

    Author : Ronny Falk; KTH.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibody generation; dual expression; affinity purification; E. coli expression; Affibody molecules; polyclonal antibody; monospecific antibody; MEDICINE Microbiology; immunology; infectious diseases Immunology Immunobiology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Immunologi Immunbiologi;

    Abstract : As many genome sequencing efforts today are completed, we are now provided with the genetic maps for several organisms, including man. With these maps at hand, the scientific focus is now shifting towards investigations of the functionality of proteins. READ MORE

  5. 5. Factors affecting body weight development and eating behaviour in patients on continuous ambulatory peritoneal dialysis treatment

    University dissertation from Stockholm : Karolinska Institutet, false

    Author : Anders Fernström; Karolinska Institutet.; Karolinska Institutet.; [1998]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CAPD; computed tomography; dual energy x-ray absorptiometry; electrogastrography; energy intake; ESRD; gastric emptying; HD; intraabdominal fat; protein-energy malnutrition; taste acuity; taste buds;

    Abstract : Continuous ambulatory peritoneal dialysis (CAPD) and hemodialysis (HD) have different meta bolic effects in dialysis patients, since absorption of intraperitoneal glucose implies an additional energy source in CAPD patients. In spite of this, protein-energy malnutrition is known to occur frequently, both in patients on hemodialysis and in patients on CAPD, and an association with increased morbidity and mortality is well established. READ MORE