Search for dissertations about: "Dynamic kinetic resolution of alcohols"

Showing result 1 - 5 of 22 swedish dissertations containing the words Dynamic kinetic resolution of alcohols.

  2. 1. Asymmetric transformation of ß- and γ-functionalized alcohols : Study of combined ruthenium-catalyzed racemization and enzymatic resolution

    Author : Annika Träff; Jan-Erling Bäckvall; Reko Leino; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Kinetic resolution; dynamic kinetic resolution; kinetic asymmetric transformation; dynamic kinetic asymmetric transformation; enzyme catalysis; racemization; asymmetric synthesis; chlorohydrin; cyano acetate; amino alcohol; metalloenzyme; bifunctional catalytic system; Organic synthesis; Organisk syntes; organisk kemi; Organic Chemistry;

    Abstract : The major part of this thesis describes the asymmetric synthesis of β- and γ-amino alcohols through the combination of ruthenium catalyzed racemization and enzymatic kinetic resolution. The dynamic kinetic resolution, DKR, protocol for chlorohydrins was improved by employing Bäckvall’s catalyst, which is a base activated racemization catalyst, in combination with Burkholderia cepacia lipase. READ MORE

  4. 2. Ruthenium-Catalyzed Hydrogen Transfer Reactions : Mechanistic Studies and Chemoenzymatic Dynamic Kinetic Resolutions

    Author : Madeleine Warner; Jan-Erling Bäckvall; Andreas Pfaltz; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Hydrogen transfer; ruthenium catalysis; kinetic resolution; dynamic kinetic resolution; racemization; asymmetric synthesis; organisk kemi; Organic Chemistry;

    Abstract : The main focus of this thesis lies on transition metal-catalyzed hydrogen transfer reactions. In the first part of the thesis, the mechanism for racemization of sec-alcohols with a ruthenium complex, Ru(CO)2Cl(η5-C5Ph5) was studied. READ MORE

  5. 3. Transition Metal- and Enzyme-Catalyzed Reactions of Primary Amines and Allylic Alcohols : Powerful Tools in the Preparation of Pharmaceutically Important Compounds

    Author : Lisa K. Thalén; Jan-Erling Bäckvall; Dirk De Vos; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Dynamic kinetic resolution; racemization; catalysis; hydrogen transfer; kinetic resolution; norsertraline; alpha-methyl carboxylic acids; pipecoloxylidide; organisk kemi; Organic Chemistry;

    Abstract : Dynamic kinetic resolution (DKR) has been applied to primary amines utilizing a ruthenium catalyst and an (R)-selective lipase to provide the corresponding amides in up to 95% isolated yield and up to >99% ee. Further investigations of the chemoenzymatic DKR of amines show that it is general and can be applied to a wide range of amines. READ MORE

  6. 4. Chemoenzymatic Dynamic Kinetic Resolution of Primary Amines and Allylic Alcohols : The Preparation of Pharmaceutically Important Compounds

    Author : Lisa K. Thalén; Stockholms universitet; []
    Keywords : ;

    Abstract : .... READ MORE

  7. 5. Chemoenzymatic Dynamic Kinetic Resolution of Functionalized Secondary Alcohols

    Author : Richard Lihammar; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Dynamic kinetic resolution (DKR) is the combination of a kinetic resolution with an in situ racemization and is a powerful method for obtaining optically active compounds. In this thesis various secondary alcohols are transformed to their corresponding enantiomerically enriched acetates by employing immobilized lipases as resolution catalysts and transition metal complexes as racemization catalysts. READ MORE