Search for dissertations about: "Dynamin 2"

Showing result 1 - 5 of 11 swedish dissertations containing the words Dynamin 2.

2. 1. Sorting nexin 9 in clathrin-mediated endocytosis

   Author : Richard Lundmark; Sven Carlsson; Elizabeth Smythe; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; sorting nexin; dynamin; clathrin; endocytosis; human; adaptor protein complexes; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; medicinsk biokemi; Medical Biochemistry;

   Abstract : Clathrin-mediated endocytosis is a process by which cells can internalise diverse molecules such as nutrients, antigens and signalling-surface receptors. The creation of clathrin-coated vesicles demands interplay between the plasma membrane lipids, cargo molecules and the proteins that build up the coat. READ MORE

4. 2. Coordination of endocytosis at the synaptic periactive zone

   Author : Emma Evergren; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Synapse; endocytosis; clathrin; dynamin; amphiphysin; synapsin; intersectin; actin cytoskeleton; immunogold electron microscopy.;

   Abstract : Neurons in the central nervous system communicate via specialized junctions called synapses. Neurotransmitter-filled vesicles are clustered at these junctions, where they are released in response to synaptic activity. To sustain reliable neurotransmission the synaptic vesicles are recycled locally. READ MORE

5. 3. The role of KIF1Bß in neuroblastoma tumour suppression during sympathetic neuron development

   Author : Stuart Fell; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Neuroblastoma, the most common extra-cranial childhood tumour, is believed to arise from precursor cells of the sympathetic nervous system (neuroblasts). Hemizygous loss of chromosome 1p36 strongly correlates with poor prognosis in neuroblastoma and the 1p36 gene KIF1Bβ has been proposed to be a pathogenic target of this deletion. READ MORE

6. 4. Studies on hereditary spastic paraplegia proteins

   Author : Cynthia Soderblom; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The hereditary spastic paraplegias (HSPs) are a clinically and genetically diverse group of inherited neurological disorders that primarily cause progressive spasticity and weakness in the lower limbs due to a length-dependent, retrograde degradation of the corticospinal motor neurons. Purely spastic paraplegia is also known as uncomplicated HSP, but complicated forms of HSP exist as well, with symptoms such as mental retardation, dementia, seizures, and optic, cortical, and cerebellar atrophy. READ MORE

7. 5. Membrane-remodeling by SNX18 in endosomal transport and autophagy

   Author : Karin Håberg; Sven Carlsson; Geir Bjørkøy; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sorting nexin; SNX9-family; SNX18; endosomal transport; autophagy; medicinsk biokemi; Medical Biochemistry;

   Abstract : The intracellular space of eukaryotic cells is subdivided into functionally distinct membrane-enclosed organelles. Regulation of these intracellular membranes requires an intricate network of specialized lipids and proteins that maintain organellar integrity and mediate transport between organelles. READ MORE