Search for dissertations about: "E1A"

Showing result 1 - 5 of 15 swedish dissertations containing the word E1A.

  2. 1. Modulation of Adenovirus E1A Activities by the Cellular Corepressor CtBP

    Author : Cecilia Johansson; Catharina Svensson; Laszlo Szekely; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Adenovirus; E1A; CtBP; transcription regulation; TetON; microarray; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : Adenovirus E1A is needed to activate early viral genes and induce cell cycle progression to optimise the conditions for viral replication. This is mostly achieved through interactions between the first exon of E1A and cellular transcriptional regulatory proteins. READ MORE

  4. 2. Characterisation of CtBP : A Co-Repressor of Transcription that Interacts with the Adenovirus E1A Protein

    Author : Anders Sundqvist; Anthony Wright; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; CtBP; HDAC; adenovirus; E1A; gene expression; repression; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

    Abstract : In this study, adenovirus E1A has been used to target and analyse the transcriptional function of the cellular C-terminal Binding Protein (CtBP).Transcription is a complex biochemical process that represents a major regulatory step in gene expression. READ MORE

  5. 3. Functional Characterization of the Evolutionarily Conserved Adenoviral Proteins L4-22K and L4-33K

    Author : Sara Östberg; Göran Akusjärvi; Stefan Schwartz; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; L4-22K; L4-33K; RNA; splicing; adenovirus; nuclear localization; replication; transcription; evolution; SR protein; MLP; promoter; E1A; serotypes;

    Abstract : Regulation of adenoviral gene expression is a complex process directed by viral proteins controlling a multitude of different activities at distinct phases of the virus life cycle. This thesis discusses adenoviral regulation of transcription and splicing by two proteins expressed at the late phase: L4-22K and L4-33K. READ MORE

  6. 4. The Modular Domain Structure of ASF/SF2: Significance for its Function as a Regulator of RNA Splicing

    Author : Vita Dauksaite; Göran Akusjärvi; Javier Caceres; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; pre-mRNA splicing; alternative splicing; splicing regulation; SR proteins; ASF SF2; modular domains; adenovirus; MLTU L1; E1A; MS2; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Abstract : ASF/SF2 is an essential splicing factor, required for constitutive splicing, and functioning as a regulator of alternative splicing. ASF/SF2 is modular in structure and contains two amino-terminal RNA binding domains (RBD1 and RBD2), and a carboxy-terminal RS domain. READ MORE

  7. 5. Splicing of adenovirus-2 E1A pre-messenger RNA : sequence requirement and the biological consequences of alternative RNA splicing

    Author : Per Johan Ulfendahl; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE