Search for dissertations about: "E2F-1"
Showing result 1 - 5 of 6 swedish dissertations containing the word E2F-1.
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1. Molecular characterization of type I endometrial carcinomas
Abstract : Endometrial carcinoma is the most common malignancy in the female reproductive tract. In Sweden over 1300 women are diagnosed every year, and although the prognosis is favourable in the majority of cases, about 160 patients die of the disease every year. READ MORE
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2. Regulation of gene transcription by the thyroid hormone receptors
Abstract : Thyroid hormone (TH) has important effects on postnatal development as well as on adult metabolic homeostasis. TH meditates its effects through different isoforms of the thyroid hormone receptors (TRs) encoded by the TRalpha and TRbeta genes, respectively. TRs belong to the nuclear hormone receptor superfamily. READ MORE
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3. Functional characterization of the alternative reading frame protein p14ARF
Abstract : A deeper understanding of the molecular events underlying tumor development is a prerequisite for the design of novel and efficient therapies. Inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways appears as a common theme in most malignant human tumors. READ MORE
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4. Proteins influencing the integrity of meiotic chromosome dynamics
Abstract : Aneuploidy (trisomy or monosomy) is the leading genetic cause of human pregnancy loss and results from aberrant meiotic chromosome segregation. Accurate segregation of meiotic chromosomes depends on extensive pairing (called synapsis) and recombination between them. READ MORE
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5. Hormonal regulation of HES-1 in breast cancer cells
Abstract : Hairy and Enhancer of Split homolog 1 (HES-1) is a transcriptional repressor belonging to the basic helix-loop-helix family of proteins, and has been shown to have a pivotal role as a regulator of neurogenesis, myogenesis and hematopoiesis. HES-1 has several well conserved domains, from Drosophila to mammals, and is expressed in a variety of tissues, in both embryos and adults. READ MORE