Search for dissertations about: "E2F"

Showing result 1 - 5 of 21 swedish dissertations containing the word E2F.

  2. 1. Role of MYCN in retinoblastoma : From carcinogenesis to tumor progression

    Author : Hanzhao Zhang; Finn Hallböök; Johan Holmberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MYCN; retinoblastoma; RNA sequencing; cancer; avian; E2F; carcinogenesis; Developmental Neurosciences; Medicinsk utvecklings- och neurobiologi;

    Abstract : Retinoblastoma, a pediatric malignancy of the retina, is primarily driven by the bi-allelic inactivation of the RB1gene. However, a subset of cases are characterized by proficient RB1 functions but with MYCN copy number mutations, suggesting an alternative oncogenic mechanism in the absence of RB1 mutations. READ MORE

  4. 2. Molecular characterization of type I endometrial carcinomas

    Author : Kristina Levan; Göteborgs universitet; []
    Keywords : endometrial cancer; gene expression; Rb1; E2F-1;

    Abstract : Endometrial carcinoma is the most common malignancy in the female reproductive tract. In Sweden over 1300 women are diagnosed every year, and although the prognosis is favourable in the majority of cases, about 160 patients die of the disease every year. READ MORE

  5. 3. Regulation of gene transcription by the thyroid hormone receptors

    Author : Maria Nygård; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Thyroid hormone receptors; T3; cell differentiation; gene regulation; E2F-1; Necdin; TRH; nTRE; RXR; NCoR; XAP-2;

    Abstract : Thyroid hormone (TH) has important effects on postnatal development as well as on adult metabolic homeostasis. TH meditates its effects through different isoforms of the thyroid hormone receptors (TRs) encoded by the TRalpha and TRbeta genes, respectively. TRs belong to the nuclear hormone receptor superfamily. READ MORE

  6. 4. Functional characterization of the alternative reading frame protein p14ARF

    Author : Mikael Lindström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : p14ARF; p19ARF; alternative reading frame; CDKN2A; p53; B23; nucleophosmin; Burkitt´s lymphoma; nucleolus; senescence; Myc; E2F; phosphorylation; RNA interference; ribosome biogenesis;

    Abstract : A deeper understanding of the molecular events underlying tumor development is a prerequisite for the design of novel and efficient therapies. Inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways appears as a common theme in most malignant human tumors. READ MORE

  7. 5. Infrared spectroscopic studies : from small molecules to large

    Author : Nadejda Eremina; Andreas Barth; Silvia Maria Doglia; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Infrared spectroscopy; transcription factors; DNA; creatine kinase; CaATPase; water; ligand binding; biofarmaci; Biopharmaceutics;

    Abstract : Infrared light (IR) was first discovered by Friedrich Wilhelm Herschel in 1800. However, until 1940’s, molecular IR studies involved only water and small organic molecules, because of the long measurement times. READ MORE