Search for dissertations about: "E3 adaptor"

Showing result 1 - 5 of 7 swedish dissertations containing the words E3 adaptor.

2. 1. Functional Characterization of the Yeast Tumour Suppressor Homologue Sro7p

   Author : Annabelle Forsmark; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Yeast; protein sorting; protein secretion; L 2 GL; tumour suppressor; SRO7; SRO77; ENA1; exocytosis; post-Golgi vesicles; ART5; E3 adaptor; ubiquitylation; ATLGL1; ATLGL2;

   Abstract : Correct targeting of newly synthesized proteins to appropriate domains of the cell membrane is crucial to cellular architecture, polarity and function, making it no surprise that many proteins of the secretory machinery are conserved throughout evolution. This work presents a functional characterisation of the Saccharomyces cerevisiae cell polarity protein and tumour suppressor homologue, Sro7p. READ MORE

4. 2. Regulation of insulin-like growth factor-1 receptor expression and signaling

   Author : Radu Vasilcanu; Karolinska Institutet; Karolinska Institutet; []
   Keywords : IGF-1R; â-arrestins; MDM2; ubiquitination; internalization;

   Abstract : Insulin-like growth factor-1 receptor (IGF-1R), a member of the insulin receptor tyrosine kinase family is a broadly expressed transmembrane receptor that plays a key role in malignant cell growth. IGF-1R transmits information provided by extracellular stimuli into intracellular signaling pathways resulting in the subsequent regulation of various effector systems. READ MORE

5. 3. Molecular mechanisms for activation of non-canonical TGFβ pathways and their importance during prostate cancer progression

   Author : Anahita Hamidi; Marene Landstöm; Carl-Henrik Heldin; Ramin Massoumi; Uppsala universitet; []
   Keywords : TGFβ; AKT; PI3K; p85α; TRAF6; TAK1; NF-κB; Src; prostate cancer; PC-3U; cell migration; inflammation; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

   Abstract : Prostate cancer is the most common invasive cancer diagnosed in men and a major and growing health problem in Western countries. Deregulation of different pathways has been implicated in progression of prostate cancer, namely nuclear factor kappa enhancer binding protein (NF-κB), transforming growth factor β (TGFβ), phosphoinositide 3ʹ-kinase/AKT (PI3K/AKT) and Src kinase pathways. READ MORE

6. 4. Regulation of PDGFRβ signaling 

   Author : Piotr Wardęga; Johan Lennartsson; Edvard Smith; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; PDGF; HD-PTP; Alix; Cbl; Ub; Fer; Y857; Y771; downregulation; degradation; ubiquitination; activation loop; Cell and molecular biology; Cell- och molekylärbiologi; Medical Cell Biology; Medicinsk cellbiologi;

   Abstract : Platelet-derived growth factor (PDGF) isoforms, which bind to closely related a- and b-tyrosine kinase receptors, induce migration, proliferation, survival and differentiation of mesenchymal cells. They signal by the active receptor attracting Src homology 2 (SH2) domain containing proteins, which subsequently initiate a set of signaling pathways. READ MORE

7. 5. Studies on the normal and oncogenic signaling networks from the hematopoietic growth factor receptors c-Kit and Flt3

   Author : Kristina Masson; Institutionen för translationell medicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : The closely related receptor tyrosine kinases c-Kit and Flt3 are mainly expressed in hematopoietic cells and are involved in driving cell proliferation and promoting survival in response to growth factor stimulation. Several gain-of-function mutations of both c-Kit and Flt3 have been found in malignancies like acute myeloid leukemia, gastrointestinal stroma tumors and small cell lung carcinomas, and the constitutively activated receptors are very potent oncogenes. READ MORE