Search for dissertations about: "E3-ligase"

Showing result 1 - 5 of 35 swedish dissertations containing the word E3-ligase.

  1. 1. A study on the E3 ligase TRIM21/Ro52

    University dissertation from Stockholm : Karolinska Institutet, Department of Medicine

    Author : Alexander Espinosa; Karolinska Institutet.; Karolinska Institutet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Patients with the systemic autoimmune diseases Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE), often have antibodies against the intracellular protein TRIM21/Ro52. Although the presence of anti- TRIM21/Ro52 autoantibodies is used as a diagnostic tool, the biological function of TRIM21/Ro52 is still unknown. READ MORE

  2. 2. The TRIM21/Ro52 E3 ligase and its antibodies in autoimmune disease

    University dissertation from Stockholm : Karolinska Institutet, Dept of Medicine, Solna

    Author : Aurélie Ambrosi; Karolinska Institutet.; Karolinska Institutet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Patients with the systemic autoimmune diseases systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS) often have autoantibodies against Ro/SSA (composed of the TRIM21/Ro52 and Ro60 antigens) and La/SSB. The biological function of the TRIM21/Ro52 protein itself has remained unknown until its recent description as a tripartite-motif (TRIM) family member and an E3 ligase involved in ubiquitination. READ MORE

  3. 3. Regulation of insulin-like growth factor-1 receptor expression and signaling

    University dissertation from Stockholm : Karolinska Institutet, Department of Oncology-Pathology

    Author : Radu Vasilcanu; Karolinska Institutet.; Karolinska Institutet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IGF-1R; â-arrestins; MDM2; ubiquitination; internalization;

    Abstract : Insulin-like growth factor-1 receptor (IGF-1R), a member of the insulin receptor tyrosine kinase family is a broadly expressed transmembrane receptor that plays a key role in malignant cell growth. IGF-1R transmits information provided by extracellular stimuli into intracellular signaling pathways resulting in the subsequent regulation of various effector systems. READ MORE

  4. 4. Molecular mechanisms for activation of non-canonical TGFβ pathways and their importance during prostate cancer progression

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anahita Hamidi; Uppsala universitet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGFβ; AKT; PI3K; p85α; TRAF6; TAK1; NF-κB; Src; prostate cancer; PC-3U; cell migration; inflammation; Biologi med inriktning mot molekylär cellbiologi; Biology with specialization in Molecular Cell Biology;

    Abstract : Prostate cancer is the most common invasive cancer diagnosed in men and a major and growing health problem in Western countries. Deregulation of different pathways has been implicated in progression of prostate cancer, namely nuclear factor kappa enhancer binding protein (NF-κB), transforming growth factor β (TGFβ), phosphoinositide 3ʹ-kinase/AKT (PI3K/AKT) and Src kinase pathways. READ MORE

  5. 5. TRIM21/ Ro52 in B cell pathology

    University dissertation from Stockholm : Karolinska Institutet, Dept of Medicine, Solna

    Author : Susanna Brauner; Karolinska Institutet.; Karolinska Institutet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease affecting 0.2% of the population. Several B cell aberrances have been linked to pSS, such as autoantibody production, hypergammaglobulinemia and B cell associated genetic polymorphisms. In addition, pSS patients display a 16 fold increased risk to develop B cell lymphomas. READ MORE