Search for dissertations about: "E3-ligase"

Showing result 16 - 20 of 40 swedish dissertations containing the word E3-ligase.

  2. 16. Molecular characterization of the cancer susceptibility protein wrap53β in Cajal body formation and DNA repair

    Author : Sofia Henriksson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : WRAP53β is a multifaceted protein involved in several biological processes including Cajal body maintenance, cancer cell survival and DNA damage repair. By directing factors to Cajal bodies and DNA double-strand breaks (DSBs), WRAP53β facilitates site-specific interactions necessary for proper biological responses. READ MORE

  4. 17. Novel Roles of the Ack1 Kinase in Epithelial Biology

    Author : Giulia Pilia; Ingvar Ferby; Bengt Hallberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ack1; Epithelial homeostasis; Cell Signalling; Cancer; Apoptosis; TRAIL-R; Yap Taz; Mechanotransduction; ErbB3; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Epithelial homeostasis is maintained through integration of diverse signals that regulate cell fate. A strict control of such signals is required to prevent overproliferation and, ultimately, oncogenesis. In this thesis we identify novel roles of Activated Cdc42-associated kinase 1 (Ack1) in maintenance of epithelial homeostasis. READ MORE

  5. 18. Transcriptional regulation of ribosomal RNA gene : actin, myosin and beyond

    Author : Aishe Angeletti Sarshad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In the eukaryotic cell nucleus, actin and nuclear myosin 1c (NM1) are key regulators of RNA polymerase I (Pol I) transcription and function across the entire ribosomal RNA biogenesis pathway. At the gene level, actin interacts with Pol I and together with NM1 they have been suggested to facilitate assembly of Pol I at the gene promoter. READ MORE

  6. 19. WRAP53β and scaRNA2 on their journey to repair the DNA

    Author : Christos Coucoravas; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : WRAP53β is a multifunctional protein involved in several cellular processes like Cajal body formation, telomere maintenance and DNA repair. WRAP53β is responsible for targeting factors to specific cellular locations, and its very high affinity for the scaRNAs could implicate these molecules in similar biological functions. READ MORE

  7. 20. Unwrapping the role of WRAP53β in DNA damage response

    Author : Hanif Rassoolzadeh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : WRAP53β is a WD40 domain protein with multifaceted capabilities in several biological processes in different cellular compartments. This includes transportation of the Survival of motor neuron (SMN) complex, small Cajal body-specific (sca) RNAs and the telomerase enzyme to Cajal bodies, as well as targeting of the E3 ligase RNF8 to DNA double-strand breaks (DSBs). READ MORE