Search for dissertations about: "EBNA1"

Showing result 16 - 20 of 30 swedish dissertations containing the word EBNA1.

  2. 16. Studies of Cellular Regulatory Mechanisms : from Genetic Switches to Cell Migration

    Author : Maria Werner; Erik Aurell; Ulrich Gerland; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Plasma physics; Plasmafysik;

    Abstract : Cellular behaviour depends ultimately on the transcription of genes. If we know how transcription is controlled we have a better chance of understanding cellular processes. This thesis presents six studies, all concerning cellular regulatory mechanisms. One study is purely experimental and five are computational studies. READ MORE

  4. 17. Regulation of the ubiquitin-proteasome system : characterization of viral and cellular stabilization signals

    Author : Stijn Heessen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Epstein-Barr virus EBV ; glycine-alanine GA repeat; green fluorescent protein GFP ; degron; proteasome; Rad23; ubiquitin; ubiquitin- associated UBA domain;

    Abstract : The ubiquitin-proteasome system plays a fundamental role in virtually every cellular process. Degradation of endogenous proteins by this system is the major source for antigenic peptides that are presented to MHC class I-restricted cytotoxic T cells. READ MORE

  5. 18. The impact of microenvironmental factors on EBV carrying B cells

    Author : Liang Wu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Epstein-Barr virus (EBV) is a human gamma-herpes virus that colonized more than 90% of the adult population. The virus is able to infect and immortalize B lymphocytes both in vitro and in vivo. READ MORE

  6. 19. Epstein-Barr virus (EBV) latent membrane protein (LMP) 2A

    Author : Fu Chen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Epstein-Barr virus (EBV) is a ubiquitous human herpes virus which infects more than 90% of individuals in the population and is causally implicated in lymphoid and epithelial malignancies. Virus invades oropharyngeal mucosa and establishes latency in memory B lymphocytes. READ MORE

  7. 20. T-cell mediated control of Epstein-Barr virus infection : viral mechanisms of immune escape

    Author : Jelena Vladmirovna Levitskaya; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Epstein-Barr virus; Cytotoxic T lymphocyte; CTL epitope; viral immunescape;

    Abstract : Mechanisms regulating the immunogenicity of Epstein-Barr Virus (EBV)-encoded CTL peptide epitopes and their contribution to the escape of virus infected cells from CTL-mediated immunosurveillance were the subject of these studies. It was demonstrated that two HLA A11-restricted CTL epitopes of EBV nuclear antigen (EBNA)-4 (designated IVT and AVF) possessed different immunogenicity that appeared to be due to a rapid surface turnover of All molecules containing the AVF peptide. READ MORE