Search for dissertations about: "EBNA1"

Showing result 21 - 25 of 27 swedish dissertations containing the word EBNA1.

  1. 21. On diverse biophysical aspects of genetics : from the action of regulators to the characterization of transcripts

    Author : Aymeric Fouquier D´Hérouel; Erik Aurell; Felix Ritort; KTH; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; transcription regulation; regulatory motifs; binding affinity; genetic interactions; secondary structure; sequence repeats; transcript characterization; Biological physics; Biologisk fysik;

    Abstract : Genetics is among the most rewarding fields of biology for the theoretically inclined, offering both room and need for modeling approaches in the light of an abundance of experimental data of different kinds. Many aspects of the field are today understood in terms of physical and chemical models, joined by information theoretical descriptions. READ MORE

  2. 22. Employing epigenetic marks to detect cancer : studies on nasopharyngeal carcinoma and lung cancer

    Author : Imran Nawaz; Karolinska Institutet; Karolinska Institutet; []

    Abstract : Tumor suppressor genes (TSGs) or oncogenes aberrantly methylated in transcription control regions during early carcinogenesis are potential tools for early detection of cancer. We have identified suitable genes and explored assays based on their methylation status aiming for early detection of cancer: nasopharyngeal carcinoma (NPC) and non-small cell lung cancer (NSCLC). READ MORE

  3. 23. Exploring the cancer cell attractor in the Epstein-Barr virus infection model

    Author : Qin Li; Karolinska Institutet; Karolinska Institutet; []

    Abstract : It has been proposed, based on the theory of complex gene regulatory networks, that cell types, including cancer cells, represent attractor states of the network dynamics. In this study, we proposed an Epstein - Barr virus (EBV) latency I to latency III switch model. READ MORE

  4. 24. Transcriptional regulation of the latent membrane protein 1 gene by Epstein-Barr virus nuclear antigen 2

    Author : Lars Palmqvist; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epstein-Barr virus; B-cell; transformation; LMP1; EBNA2; transcription; phosphorylation; histone acetylation;

    Abstract : The Epstein-Barr virus (EBV) is a ubiquitous human herpes virus, which infects B-cells. This leads to a life-long latent infection, which in most cases is non-pathogenic. However, EBV is etiologically associated with several human malignancies, including endemic Burkitt's lymphoma, nasopharyngeal carcinoma and post-transplant lymphoma. READ MORE

  5. 25. Risk and prognostic factors for malignant glioma

    Author : Sara Sjöström; Beatrice S Melin; Ulrika Andersson; Monika Hegi; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioma; Glioblastoma; Risk; Outcome; EGR; EGFR; VEGF; VEGFR; DNA repair; virus; Oncology; Onkologi; onkologi; Oncology;

    Abstract : Background: Glioblastoma is the most common and aggressive type of glioma and associated with poor prognosis. Apart from ionizing radiation and some rare genetic disorders, few aetiological factors have been identified for primary brain tumours. READ MORE