Search for dissertations about: "EBNA1"
Showing result 6 - 10 of 30 swedish dissertations containing the word EBNA1.
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6. Interaction of the genome maintenance proteins of oncogeneic herpesviruses with cellular chromatin
Abstract : The Epstein-Barr virus (EBV) nuclear antigen (EBNA)-1 is the only viral protein expressed in all virus-infected cells and EBV-associated malignancies. Similar to the genome maintenance proteins (GMPs) of other gamma-herpesviruses, EBNA1 binds to both viral and cellular DNA and controls the replication and transcription of the viral genome. READ MORE
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7. Epstein-Barr virus and genomic instability : a new look at the mechanisms of viral oncogenesis
Abstract : EBV is associated with a variety of lymphoid and epithelial malignancies but the mechanisms of oncogenesis are still not fully understood. The aim of the work described in this thesis was to assess whether induction of genomic instability, as defined by the accumulation of non-clonal genetic aberrations, could play a role in EBV oncogenesis and identify the viral protein(s) responsible for this phenotype. READ MORE
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8. Regulation and expression of Epstein-Barr virus nuclear antigen 1 in transplant patients and cell culture
Abstract : Epstein-Barr virus (EBV) is a human herpes virus that infects over 90% of the world population. Once infection has occurred, the virus persists for life in its host, mainly in an asymptomatic, latent stage with only a few active viral genes. READ MORE
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9. Common viruses and host gene interactions in multiple sclerosis
Abstract : Multiple sclerosis (MS) is a neurological disorder, characterised by demyelination and inflammation of the central nervous system, leading to sensory and motor symptoms. MS is thought to be complex disease, with both environmental and genetic risk factors underlying disease susceptibility. READ MORE
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10. Epstein-Barr virus nuclear antigen 1, Oct and Groucho/TLE in control of promoter regulation
Abstract : The human herpes virus Epstein-Barr virus (EBV) is carried by approximately 95% of the adult population. It can form a lifelong latent infection in the B-cells by avoiding our immune system. A latent EBV infection is usually asymptomatic but a few EBV associated cancer forms has been described (e.g. READ MORE