Search for dissertations about: "EBV"
Showing result 21 - 25 of 151 swedish dissertations containing the word EBV.
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21. Mechanisms of immune escape in EBV associated malignancies : Hodgkin's disease and Burkitt's lymphoma
Abstract : The work presented in this thesis is focused on the analysis of the mechanisms operating in the immune escape of two Epstein-Barr virus (EBV) associated tumors: Hodgkin's Disease (HD) and Burkitt's lymphoma (BL). EBV positive HD tumor cells express at least 3 viral proteins: the EBV nuclear antigen (EBNA)1, the latent membrane proteins (LMP)1 and LMP2A. READ MORE
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22. Strategies for management of EBV and adenovirus infections after allogeneic stem cell transplantation
Abstract : Viral infections are one of the challenges that can threaten successful allogeneic HSCT especially during the period of immune reconstitution resulting in a high mortality risk. Adenoviruses and EBV are important viruses during this period. READ MORE
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23. Role of latent EBV genes in the induction of genomic instability in Burkitt’s lymphoma
Abstract : Epidemiological and molecular evidence link Epstein-Barr virus (EBV) infection to a variety of lymphoid and epithelial malignancies but the contribution of the virus to tumorigenesis is unclear. Genomic instability, defined by the establishment of a mutator phenotype and characterized by the occurrence of non-clonal chromosomal aberrations, excessive DNA damage and defects in DNA repair, is the hallmark of malignant transformation. READ MORE
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24. Nuclear compartmentalization of viral and cellular proteins involved in gamma-herpes virus (EBV and HHV-8) mediated cellular transformation
Abstract : The aim of the work described in this thesis has been to characterize the nuclear compartmentalization of cellular and viral proteins involved in EBV or HHV-8 mediated cellular transformation. We have studied the EBV encoded EBNA-5 and its association with the PML nuclear bodies (NBs) and nuclear inclusions. READ MORE
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25. Analysis of viral and cellular gene expression patterns in cells latently infected with EBV by suppression subtractive hybridization
Abstract : Epstein-Barr virus is a ubiquitous γ-herpes virus and causes the self-limiting lymphoproliferative disease, called infectious mononucleosis. Its presence is associated with several malignancies, including Burkitt lymphoma, gastric cancer and other malignant diseases. READ MORE