Search for dissertations about: "ECM"

Showing result 16 - 20 of 245 swedish dissertations containing the word ECM.

2. 16. Tissue remodelling in pulmonary fibrosis linked to 5-HT2 receptor activation

   Author : Anna Löfdahl; Lungbiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Serotonin 5HT ; Serotonin class 2 receptor antagonist; Fibroblast; Pulmonary fibrosis; Extracellular matrix ECM ;

   Abstract : After an injury, an immediate reparative response is triggered to replace the damaged tissue, however, in fibrosis, cells remain active despite wound resolution causing a steady build-up of fibrotic tissue. In pulmonary fibrosis,there is a constant regeneration and remodelling of lung tissue where the thin architecture of alveoli become thickened, hampering efficient diffusion of oxygen, as seen in diseases like idiopathic pulmonary fibrosis (IPF). READ MORE

4. 17. Graffiti – For Joy and Confirmation. Motivational aspects, triggering and inhibiting factors, and emotional satisfactions in graffiti: The creative-interactive dimension of vandalism

   Author : Anki Nordmarker; Göteborgs universitet; []
   Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; vandalism; scrawl; graffiti; personality traits; frustration; motivation; joy; flow; satisfaction; the extended Eguity Control Model of Vandalism; e-ECM 2016 ;

   Abstract : The purpose of the present dissertation is to achieve a deeper understanding about what motivates young people to commit vandalism in general and scrawl-graffiti in particular, and what this propensity provides in the form of satisfaction and/or further motivation. The present thesis consists of two experimental studies, one questionnaire study, and one interview study, of a total of 515 participants (287 male, 219 female, 9 missing gender). READ MORE

5. 18. The identification and functional evaluation of novel cancer-associated fibroblast subtypes and matrisome proteins in pancreatic cancer

   Author : Joshua Cumming; Daniel Öhlund; Cedric Patthey; Jenny Persson; Claus Jørgensen; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer-associated fibroblast CAF ; Single-cell RNA sequencing scRNAseq ; Pancreatic ductal adenocarcinoma PDAC ; Tumor microenvironment TME ; Extracellular matrix ECM ; Organoid-based co-culture model; Drug-screen; Oncology; onkologi;

   Abstract : Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy characterized by an extensive desmoplastic stroma. The stroma is the site of intricate communication between malignant cells and their surrounding environment. READ MORE

6. 19. Joint disease biomarkers - discovery and application

   Author : Dovilė Sinkevičiūtė; Reumatologi och molekylär skelettbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Osteoarthritis; Psoriatic arthritis; cartilage; Proteomics; Biomarkers; ELISA; Tissue culture; Extracellular matrix ECM ;

   Abstract : Dysregulated cartilage homeostasis, articular cartilage degradation and abnormal bone remodeling are common denominators in joint disease and can lead to severe disability for the patients. The molecular pathways behind the disease pathology can overlap across different joint diseases. READ MORE

7. 20. Axon Guidance and Morphogenesis of the C. elegans Pharynx

   Author : Manish Rauthan; Chalmers tekniska högskola; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharynx; M2; C. elegans; extra-cellular matrix ECM ; hex; Krüppel; pha-2; isthmus; NSM; pharyngeal neurons.; cytoskeleton; mnm-2;

   Abstract : The C. elegans pharynx is a single cell thick muscular tube that undergoes morphogenesis to attain it mature structure from a ball of 80 undifferentiated cells. This thesis is about understanding the mechanisms and the genetic pathways underlying the process of pharyngeogenesis. READ MORE