Search for dissertations about: "EDC derivatization"

Found 1 swedish dissertation containing the words EDC derivatization.

2. 1. Chemical Derivatization in Combination with Liquid Chromatography Tandem Mass Spectrometry for Detection and Structural Investigation of Glucuronides

   Author : Matilda Lampinen Salomonsson; Mikael Hedeland; Ulf Bondesson; Calle Nilsson; Uppsala universitet; []
   Keywords : Pharmaceutical chemistry; Derivatization; mass spectrometry; glucuronide; drug metabolism; increased sensitivity; structural investigation; 2-chloro-1-methylpyridinium iodide CMPI ; 1-ethyl-3- 3-dimethylaminopropyl -carbodiimide EDC ; 2-picolylamine PA ; 1; 2-dimethylimidazole-4-sulfonyl chloride DMISC ; Farmaceutisk kemi;

   Abstract : This thesis presents novel approaches for structural investigation of glucuronides using chemical derivatization in combination with liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MSn).Today, LC-ESI-MSn is the dominant technique for quantitative as well as qualitative analyses of metabolites, due to its high sensitivity and selectivity. READ MORE