Search for dissertations about: "EGFR breast cancer"

Showing result 1 - 5 of 19 swedish dissertations containing the words EGFR breast cancer.

  2. 1. Breast cancer : Multifocality, heterogeneity, and related genetic signatures

    Author : Gyula Pekar; Dumanski Jan; Sapino Anna; Uppsala universitet; []
    Keywords : breast; breast cancer multifocality; molecular phenotypes; intertumoral heterogeneity; biobanking; gene copy number aberrations;

    Abstract : Breast carcinoma often exhibits a complex subgross morphology and may occupy a large volume of the breast tissue and show unifocal, multifocal or diffuse growth patterns. Expression of estrogen- and progesterone receptors, HER2 overexpression, tumor grade, and proliferative activity allows us to classify breast carcinoma into molecular subgroups (Luminal A, Luminal B, HER2-type, triple negative, and basal-like). READ MORE

  4. 2. Genomic Profiling, Mutations and Deranged Signaling in Esophageal Cancer and Hereditary Colorectal Cancer

    Author : Anna Isinger Ekstrand; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Esophageal cancer; hereditary cancer; HNPCC; copy number analysis; CGH; gene expression; Wnt; PIK3CA; CHEK2; gastric cancer; colorectal cancer;

    Abstract : Esophageal cancer and colorectal cancer represents two major types of gastrointestinal tumors. Though refined surgery and introduction of novel chemotherapeutics have improved outcome, more than 2500 Swedes die from these diseases every year. Novel markers for early diagnosis, prognosis and treatment prediction are therefore needed. READ MORE

  5. 3. Molecular Analysis of Breast Cancer Transcriptomes, Genomes, and Circulating Tumor DNA

    Author : Eleonor Olsson; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer stem cells; RNA splicing; breast cancer; mutations; circulating tumor DNA; early detection of recurrent breast cancer; sequencing;

    Abstract : Breast cancer is a very heterogeneous disease in terms of clinical characteristics, genetic aberrations and prognosis. In Paper I, we focused on the CD44 molecule that often is aberrantly expressed in breast cancer and is widely used as a marker for cancer stem cells. READ MORE

  6. 4. Aspects of Progression in Breast Carcinoma : from ductal carcinoma in situ to invasive cancer

    Author : Wenjing Zhou; Fredrik Wärnberg; Marie-Louise Fjällskog; Carl Blomqvist; Malin Sund; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; progression; ductal carcinoma in situ; breast cancer; Medicinsk vetenskap; Medical Science;

    Abstract : In the past decades our knowledge concerning breast cancer progression from ductal carcinoma in situ (DCIS) to invasive cancer has grown rapidly. However, molecular factors driving the progression are still largely unknown. READ MORE

  7. 5. LRIG1 in lung cancer : prognostic effects and mechanistic studies

    Author : Samuel Kvarnbrink; Mikael Johansson; Håkan Hedman; Odd Terje Brustugun; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lung cancer; metastasis; prognosis; LRIG1; LRIG3; LMO7; LIMCH1; Oncology; onkologi;

    Abstract : Lung cancer is the leading cause of cancer-related death worldwide as well as in Sweden. Non-small cell lung cancer (NSCLC) is the predominant form, which is largely subdivided into adenocarcinomas and squamous cell carcinomas. READ MORE