Search for dissertations about: "EGFR"

Showing result 16 - 20 of 178 swedish dissertations containing the word EGFR.

2. 16. Ubiquitination and Receptor Endocytosis

   Author : Kaisa Haglund; Carl-Henrik Heldin; Ivan Dikic; Harald Stenmark; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Ubiquitination; receptor tyrosine kinase; endocytosis; Cbl; CIN85; EGFR; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

   Abstract : Protein ubiquitination is an evolutionary conserved mechanism that controls a wide variety of cellular functions. Polyubiquitinated proteins are generally degraded in the proteasome, whereas monoubiquitination controls various other cellular processes, including endocytosis and endosomal sorting. READ MORE

4. 17. Importance of renal function in cardiac surgery

   Author : Alain Dardashti; Thoraxkirurgi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute kidney injury; eGFR; Transfusion; Mortality; Erythropoietin; Cardiac surgery;

   Abstract : Abstract Acute kidney injury (AKI) is a common and serious complication after cardiothoracic surgery and is associated with increased short- and long-term mortality risk. Despite extensive studies in the field, a comprehensive understanding of this syndrome has remained elusive, partly due to divergent definitions of AKI and partly due to the limitations of available routine biomarkers to predict, prevent, and detect AKI. READ MORE

5. 18. Prognosis, Prediction and Risk Assessment in the Prevention and Treatment of Non-Small Cell Lung Cancer

   Author : Martin Sandelin; Christer Janson; Henrik Riska; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chemoradiation therapy; induction chemotherapy; thrombocytosis; anaemia; leucocytosis; EGFR; guidelines; molecular pathology; ACOS; COPD; risk assessment; comorbidities; Lung Medicine; Lungmedicin;

   Abstract : Background: Lung cancer causes more deaths than any other cancer. Smoking causes roughly 90% of lung cancer cases. Concurrent chemoradiation therapy is the standard of care for stage IIIb patients with performance status (PS) 0-1. A less toxic approach is warranted for less fit patients. READ MORE

6. 19. Biomolecular markers in head and neck cancer

   Author : Eva Lindell Jonsson; Göran Laurell; Karin Nylander; Marika Nestor; Linda Marklund; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Head and neck cancer; Biomolecular markers; Radiation; Radiation-induced mucositis; Oral Tongue Squamous Cell Carcinoma; Metabolomics; EGFR; Hyaluronan; Mast cells; Neutrophils; Oto-Rhino-Laryngology; Oto-rhino-laryngologi;

   Abstract : Head and neck cancer is a heterogeneous group of tumours, of which certain subgroups such as cancer of the mobile tongue frequently are associated with a relatively poor prognosis due to the high risk of regional failure and mortality rates that haven’t improved in a significant way over the last 3 decades, despite advancements in both diagnostics and treatment.Today we lack means to assess the biological aggressiveness of each individual tumour, which varies largely. READ MORE

7. 20. Prognostic role of tumour associated trypsin inhibitor in colorectal cancer patients

   Author : Alexander Gaber; Tumörmikromiljö; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; KRAS mutation; ERK1 2; TATI; Colorectal cancer; Prognosis; Biomarker; EGFR; STAT3;

   Abstract : Colorectal cancer (CRC) is one of the most common forms of human cancer worldwide with approximately 1 million new cases detected every year. CEA is currently the only accepted CRC marker incorporated into clinical practice, where it is used for early detection of metastasis in follow-up of patients having stage II and III disease, and for monitoring response to adjuvant treatment. READ MORE