Search for dissertations about: "EMT"

Showing result 1 - 5 of 48 swedish dissertations containing the word EMT.

  1. 1. Not all those who wander are lost : A study of cancer cells by digital holographic imaging, fluorescence and a combination thereof

    University dissertation from Department of Biology, Lund University

    Author : Sofia Kamlund; [2018-09]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Digital holography; longitudinal tracking; breast cancer stem cells; salinomycin; EMT; Digital Holography; longitudinal tracking of individual cells; breast cancer cells; Breast cancer; Salinomycin; cancer stem cells; Fluorescence microscopy; EMT;

    Abstract : Cells are commonly used in research to evaluate toxicity and efficiency of drugs. However, to further increase the usefulness of cells as well as the understandings of effects of different interventions, new methods must constantly be developed and refined. READ MORE

  2. 2. Transcriptional and Epigenetic Regulation of Epithelial-Mesenchymal Transition

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : E-Jean Tan; Aristidis Moustakas; Carl-Henrik Heldin; Geert Berx; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGFβ; EMT; HMGA2; Snail; Twist; E-cadherin; epigenetics; invasion; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : The transforming growth factor beta (TGFβ) is a cytokine that regulates a plethora of cellular processes such as cell proliferation, differentiation, migration and apoptosis. TGFβ signals via serine/threonine kinase receptors and activates the Smads to regulate gene expression. READ MORE

  3. 3. Novel Regulators of the TGF-β Signaling Pathway

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Marcin Kowanetz; Uppsala universitet.; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; TGF-β; Smad; Id; EMT; cell cycle; SNF1LK; ubiquitin; degradation; signal transduction; Cell- och molekylärbiologi; NATURAL SCIENCES Biology Cell and molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi;

    Abstract : The transforming growth factor-β (TGF-β) superfamily consists of related multifunctional cytokines, which include TGF-βs, activins, and bone morphogenetic proteins (BMPs) and coordinate several biological responses in diverse cell types. The biological activity of TGF-β members is executed by transmembrane serine/threonine kinase receptors and intracellular Smad proteins. READ MORE

  4. 4. Prognostic and Treatment Predictive Markers Associated with Cyclin D1 Gene Amplification and Epithelial-Mesenchymal Transition in Breast Cancer

    University dissertation from Katja Lundgren

    Author : Katja Lundgren; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; beta-arrestin1; Chk1; Breast Cancer; Tamoxifen; prognostic marker; predictive marker; gene amplification; cyclin D1; EMT; Snail; hypoxia;

    Abstract : Endocrine resistant breast cancer is a major therapeutical challenge and accurate selection of patients susceptible to certain types of anti-hormonal treatment strategies is pivotal. Discovery of novel biomarkers potentially predicting treatment response as well as the clinical course of breast cancer is essential to effectively improve therapies and diagnosis. READ MORE

  5. 5. Platelets – Multifaceted players in tumor progression and vascular function

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Yanyu Zhang; Anna-Karin Olsson; Gertraud Orend; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Tumor; Platelet; HRG; PDGFB; TBK1; NETs; Angiogenesis; EMT; Metastasis; Medicinsk vetenskap; Medical Science; Oncology; Onkologi; Biologi med inriktning mot molekylär cellbiologi; Biology with specialization in Molecular Cell Biology;

    Abstract : Platelets play a crucial role for blood hemostasis, the process that prevents bleeding. In addition, platelets have been demonstrated to promote cancer progression and cancer related complications like metastasis and thrombosis. READ MORE