Search for dissertations about: "EPITOPE"
Showing result 1 - 5 of 286 swedish dissertations containing the word EPITOPE.
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1. Computational Prediction Models for Proteolytic Cleavage and Epitope Identification
Abstract : The biological functions of proteins depend on their physical interactions with other molecules, such as proteins and peptides. Therefore, modeling the protein-ligand interactions is important for understanding protein functions in different biological processes. READ MORE
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2. Array-based Autoantibody Profiling and Epitope Mapping
Abstract : Antibodies are a class of proteins that are made by the immune system to recognize harmful organisms and molecules. Their exceptional capability of specifically recognizing molecules has been investigated for over a century and information thereof has been utilized for a variety of applications including vaccine and generation of therapeutic antibodies. READ MORE
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3. Epitope mapping of antibodies towards human protein targets
Abstract : This thesis, based on five research papers, presents results from development and evaluation ofmethods for identifying the interaction site of antibodies on their antigens and the functional investigation of these in different assays. As antibodies have proven to be invaluable tools in diagnostics, therapy and basic research, the demand of characterizing these binding molecules has increased. READ MORE
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4. Diagnostic and prognostic aspects of anti-neutrophil cytoplasmic antibodies in systemic vasculitis
Abstract : Primary systemic vasculitis is associated with a high mortality if left untreated and it is essential to make the diagnosis before permanent organ damage has occurred. In this thesis the diagnostic and prognostic significance of anti-neutrophil cytoplasmic antibodies (ANCA) in systemic vasculitis is investigated. READ MORE
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5. Selection of antigens for antibody-based proteomics
Abstract : The human genome is predicted to contain ~20,500 protein-coding genes. The encoded proteins are the key players in the body, but the functions and localizations of most proteins are still unknown. READ MORE