Search for dissertations about: "ERBB"
Showing result 1 - 5 of 15 swedish dissertations containing the word ERBB.
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1. The LRIG-family: identification of novel regulators of ErbB signaling with clinical implications in astrocytoma
Abstract : Astrocytic tumors are the most common malignancies of the central nervous system, accounting for more than 60% of all primary brain tumors. The prognosis for high grade astrocytoma patients is dismal and there is no curative treatment, today. READ MORE
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2. Canertinib-induced leukemia cell death signaling : effects of a pan-ERBB inhibitor
Abstract : Acute myelogenous leukemia (AML) is the most common acute leukemia affecting adults, the second most frequent leukemia in children, and remains one of the most difficult to cure. Despite a substantial progress in understanding the pathogenesis of AML, general and rather unspecific cytostatic drugs such as cytarabine and anthracyclins still make up the cornerstones of therapy. READ MORE
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3. Experimental studies on ErbB targeted therapy in malignant melanoma
Abstract : Malignant melanoma has one of the fastest increasing incidences among the different types of cancer in the Western world. This raise can partly be ascribed to the change in sun habits that has taken place during the last decades, since the major external risk factor for melanoma is exposure to ultraviolet radiation. READ MORE
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4. Experimental studies in brain tumours : with special regard to multidrug resistance and the ErbB-family
Abstract : Primary brain tumours, and especially the most common form malignant gliomas, usually display a pronounced resistance to other treatment modalities when surgery fails to cure. Growth factors, such as EGF and its receptor, frequently amplified and overexpressed in malignant gliomas, and factors associated with multidrug resistance have been suggested to at least partially explain the poor outcome. READ MORE
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5. Studies of LRIG1 and the ERBB receptor family in breast and colorectal cancer
Abstract : The LRIG1 gene (leucine-rich repeats and immunoglobulin like domains-1) at chromosome 3p14 is a proposed tumour suppressor gene whose gene product negatively regulates various receptor tyrosine kinases. This function has been the basis for classifying LRIG1 as a potential tumour suppressor gene (TSG). READ MORE