Search for dissertations about: "ERK1 2"

Showing result 11 - 15 of 103 swedish dissertations containing the words ERK1 2.

  2. 11. Injury-induced activation of vascular smooth muscle cells. Role of specific gene expression and intracellular signalling pathways

    Author : Cecilia Lövdahl; Reumatologi och molekylär skelettbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metalloproteinase; extracellular matrix; ERK1 2 signalling; migration; proliferation; injury; vessel wall; smooth muscle cell; Medicine human and vertebrates ; Medicin människa och djur ;

    Abstract : Migration and proliferation of smooth muscle cells (SMC) are important events in the development of atherosclerosis and restenosis following angioplastic surgery. It is important to gain further knowledge about the mechanisms regulating SMC form and function in order to understand the underlying disease process. READ MORE

  4. 12. Stroke, Sex and Vascular Receptor Changes in the Brain

    Author : Hilda Ahnstedt; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; endothelin receptors; Cerebral ischemia; sex; estrogen; progesterone; sex differences; human cerebral arteries; endothelin-1; angiotensin II; middle cerebral artery occlusion; extra-cellular signal regulated kinase 1 and 2;

    Abstract : Stroke is a severe cerebrovascular disease in which the neuronal tissue and vasculature of the brain undergo ischemia-evoked alterations. We have demonstrated an increased expression of cerebrovascular contractile receptors in the brain. This is hypothesized to mitigate cerebral blood flow and exacerbate tissue damage after stroke. READ MORE

  5. 13. Shb and Its Homologues: Signaling in T Lymphocytes and Fibroblasts

    Author : Cecilia Lindholm; Hamid Band; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Shb; T cell receptor; IL-2 receptor; PDGF receptor; cell signaling; adapter proteins; LAT; Vav; PLC-g1; SLP-76; JAK1; JAK3; Jurkat cells; T cells; NK cells; Apoptosis.; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : Stimulation of the T cell receptor (TCR) induces tyrosine phosphorylation of numerous intracellular proteins, leading to activation of the interleukin-2 (IL-2) gene in T lymphocytes. Shb is a ubiquitously expressed adapter protein, with the ability to associate with the T cell receptor and several signaling proteins in T cells, including: the TCR ζ-chain, LAT, PLC-γ1, Vav, SLP-76 and Gads. READ MORE

  6. 14. Exercise effects on the mitogen-activated protein (MAP) kinase cascade in skeletal muscle

    Author : Ulrika Widegren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : skeletal muscle; MAP kinase; contraction; acute exercise; Akt kinase; exercise intensity; signal transduction; fiber-type;

    Abstract : Exercise-induced adaptations in skeletal muscle are regulated by numerous signaling mechanisms. However, little is known about the molecular signaling mechanisms linking muscle contraction or other exercise-associated stimuli to intracellular responses in skeletal muscle. READ MORE

  7. 15. The role of the MAP- and SAP- kinase pathways in the survival, proliferation and death of Schwann cells of the injured sciatic nerve

    Author : Lisa Mårtensson; Funktionell zoologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : This thesis concerns alterations in signal transduction in Schwann cells as a response to nerve injury as well as their survival, proliferation and death. Enzymes and transcription factors belonging to the mitogen activated protein kinase (MAPK) and the stress activated protein kinase (SAPK) pathways were studied. READ MORE