Search for dissertations about: "ERK1 2"

Showing result 16 - 20 of 103 swedish dissertations containing the words ERK1 2.

  2. 16. TGF-beta signaling in carcinogenic transformation of breast epithelial cells, using proteomics

    Author : Nimesh Bhaskaran; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Transforming growth factor-beta (TGFbeta) is a key regulator of cell proliferation, death, migration and differentiation. One of the features of TGFbeta signaling is to inhibit tumor growth at the early stage of cancer but promotes tumorigenesis at the advanced stage. READ MORE

  4. 17. Protein Kinase Inhibition in Late Cerebral Ischemia after Subarachnoid Hemorrhage

    Author : Saema Ansar; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; neuropsychology; neurophysiology; Neurologi; protein kinase; cerebral ischemia; subarachnoid hemorrage; neurofysiologi; neuropsykologi;

    Abstract : The cerebral ischemia that occur after a subarachnoid hemorrhage (SAH) often results in death or severe disability and is a significant cause of stroke. Our hypothesis is that cerebral ischemia leads to pathophysiological receptor changes on the vascular smooth muscle cells. READ MORE

  5. 18. Orexin Receptors in Recombinant CHO Cells : Signaling to Short- and Long-Term Cell Responses

    Author : Sylwia Ammoun; Jyrki Kukkonen; Karl Åkerman; Gunnar Flemström; Christer Larsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; orexins; cell signaling; Neurovetenskap; Neurology; Neurologi;

    Abstract : Recently discovered neuropeptides orexins (orexin-A and -B) act as endogenous ligands for G-protein-coupled receptors called OX1 and OX2 receptors. Our previous studies have established model systems for investigation of the pharmacology and signaling of these receptors in recombinant CHO cells. READ MORE

  6. 19. The role of hyaluronan and its CD44 receptor in inflammation and cancer

    Author : Chun-Yu Lin; Jyrki Tenhunen; Miklós Lipcsey; Paraskevi Heldin; Markku Tammi; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD44; Dengue; Hyaluronan; HAS2; iASPP; TGFbeta; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Hyaluronan, an important extra-cellular matrix molecule, was thought to be interstitial connecting glue decades ago. However, recent evidence has revealed that hyaluronan and its binding proteins also play crucial roles in various pathophysiological conditions in humans, including inflammation and infection. READ MORE

  7. 20. TISSUE MICROARRAY PERSPECTIVES ON CYCLIN D1 IN BREAST CANCER: Progression, prognosis and prediction

    Author : Karin Jirström; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pathological anatomy; General pathology; tamoxifen resistance; CCND1; Breast cancer; tissue microarrays; Patologi allmän ; patologisk anatomi;

    Abstract : Breast cancer is a truly heterogenous disease, reflected in the existence of a wide spectrum of phenotypic subsets of tumours with varying intrinsic aggressiveness as well as ability to respond to a given treatment. Recent advances in large-scale genomic and proteomic screening techniques have confirmed this heterogeneity also at a molecular level, but there is still a bottleneck to be overcome before the discoveries in the laboratory can be translated into the much more complex clinical situation in order to develop better targeted therapies. READ MORE