Search for dissertations about: "ERK5"

Showing result 1 - 5 of 6 swedish dissertations containing the word ERK5.

  2. 1. Studies of PDGF receptor signaling in vitro and in vivo

    Author : Maria Tsioumpekou; Carl-Henrik Heldin; Jean-Baptiste Demoulin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; signaling; cancer; Erk5; kinase; Cbl; ubiquitination; deubiquitinase; pericytes; tumor growth; angiogenesis; low molecular weight inhibitors;

    Abstract : Platelet-derived growth factor receptor (PDGFR) signaling is essential for proliferation, migration and survival of cells of mesenchymal origin; however, its deregulation has been associated with various diseases, including cancer. The aim of this thesis was to clarify the molecular mechanisms of PDGFR signaling regulation. READ MORE

  4. 2. Regulation and Function of MAP Kinases in PDGF Signaling

    Author : Glenda Eger; Johan Lennartsson; Carl-Henrik Heldin; Martin Gullberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; PDGFR; MAP kinase; Erk1 2; Erk5; Dusp MKP; NR4A1; cancer; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Platelet-derived growth factor (PDGF) is a family of signaling molecules that stimulates cell growth, survival and migration. PDGF is recognized by specific transmembrane proteins, the PDGF receptors, which relay the signals to the cell activating the Mitogen-activated protein (MAP) kinases and other signaling pathways. READ MORE

  5. 3. Oncogenic ALK signaling in neuroblastoma

    Author : Ganesh Umapathy; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaplastic lymphoma kinase; neuroblastoma; ERK5; Akt; MYCN; mTOR;

    Abstract : Over the last decade Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase (RTK) has been identified as a translocation partner in diverse cancer types. In tumors, where the full-length ALK RTK itself is mutated, such as neuroblastoma, the picture is less clear regarding ALKs role as an oncogenic driver. READ MORE

  6. 4. Studies on signaling pathways induced by FLT3, an important oncogene in AML

    Author : Elena Razumovskaya; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FLT3; AML; RTK; oncogene; ERK5; hematopoiesis;

    Abstract : FLT3, a receptor tyrosine kinase, is expressed in hematopoietic progenitor cells. FLT3-ITD (internal tandem duplication) and D835 mutations are found in approximately 30% and 7% of Acute Myeloid Leukemia (AML) patients respectively, and correlate with a poor prognosis, thus making the mutated receptor a potential therapeutic target. READ MORE

  7. 5. Biological pathways in B-cell non-Hodgkin's lymphoma

    Author : Mohit Aggarwal; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Non-Hodgkin’s lymphomas have become more prevalent in the past 20 years. They constitute a diverse group of lymphoid tumors that have been understood and classified according to their clinical behaviour, anatomic location, morphology, immunophenotype, cytogenetics, and gene expression profile. READ MORE